2-tert.-Butyl.1,3-thiazolidin. | 40823-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2-tert.-Butyl.1,3-thiazolidin.
• 英文别名: 2-tert-butyl-thiazolidine；2-Tert-butyl-1,3-thiazolidine
• CAS: 40823-56-1
• 化学式: C₇H₁₅NS
• 分子量: 145.269
• InChiKey: HFRXAIUSDIPKJM-UHFFFAOYSA-N

物化性质

• 沸点：
  210.4±15.0 °C(Predicted)
• 密度：
  0.965±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  特戊醛 、 巯基乙胺 生成 2-tert.-Butyl.1,3-thiazolidin.
  参考文献：
  名称：

  Conformational studies of 1,3-thiazolidines

  摘要：

  DOI：

  10.1021/ja00812a032

文献信息

• Granular cysteamine hydrochloride and method for production thereof
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0408398B1

  公开（公告）日：1995-04-05
• METHODS FOR TREATING INFLAMMATORY DISEASE BY ADMINISTERING ALDEHYDES AND DERIVATIVES THEREOF
  申请人：ALFAMA - INVESTIGAÇÃO E DESENVOLVIMENTO DE PRODUTO

  公开号：EP2099439A2

  公开（公告）日：2009-09-16
• Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
  申请人：De Matos N. Marta

  公开号：US20070219120A1

  公开（公告）日：2007-09-20

  A method is disclosed for treating inflammatory disease in an animal in need thereof by administering to the animal a pharmaceutical composition containing an anti-inflammatory effective amount of an organic aldehyde compound or a derivative thereof in a pharmaceutically acceptable vehicle.
• NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
  申请人：Inflazome Limited

  公开号：US20200291003A1

  公开（公告）日：2020-09-17

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R 1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R 1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R 1 may optionally be substituted; and R 2 is a cyclic group substituted at the α-position, wherein R 2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.
• PHENYLSULFONYLUREA DERIVATIVES USEFUL AS NLRP3 INHIBITORS
  申请人：Inflazome Limited

  公开号：US20210332020A1

  公开（公告）日：2021-10-28

  The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted with a monovalent group comprising either (i) an aryl or a heteroaryl group, or (ii) a nitrogen-containing heterocyclic group, and wherein the group attached to the terminal nitrogen atom of the urea group is a 6-membered cyclic group substituted at the 2- and 4-positions. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP 3 inhibition.