N-(2-benzoylphenyl)-2-methoxy-4-methylbenzamide | 1343483-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-benzoylphenyl)-2-methoxy-4-methylbenzamide
• CAS: 1343483-67-9
• 化学式: C₂₂H₁₉NO₃
• 分子量: 345.398
• InChiKey: NOCOSJKVGBPQGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 2-(p-Toluoylamino)benzophenon 在 碘苯二乙酸 、 palladium diacetate 作用下， 反应 8.0h， 以75%的产率得到N-(2-benzoylphenyl)-2-methoxy-4-methylbenzamide
  参考文献：
  名称：

  Regioselective ortho-acetoxylation/methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C–H activation

  摘要：

  A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)(2) (10 mol %) and a stoichiometric amount of Phl(OAc)(2) in a mixture of acetic anhydride and acetic acid via C-H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.098

文献信息

• Regioselective ortho-acetoxylation/methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C–H activation
  作者：B.V. Subba Reddy、G. Revathi、A. Srinivas Reddy、J.S. Yadav

  DOI：10.1016/j.tetlet.2011.08.098

  日期：2011.11

  A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)(2) (10 mol %) and a stoichiometric amount of Phl(OAc)(2) in a mixture of acetic anhydride and acetic acid via C-H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions. (C) 2011 Elsevier Ltd. All rights reserved.