α-methyldopa ethyl ester | 14298-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-methyldopa ethyl ester
• 英文别名: Ethyl 2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
• CAS: 14298-24-9
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: SVEBYYWCXTVYCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• COMPOUND AND USE THEREOF
  申请人：Feliqs Corporation

  公开号：EP4101839A1

  公开（公告）日：2022-12-14

  Provided is a compound that achieves a good balance between the LO• scavenging ability and the LOO• scavenging ability. The compound of the present invention or a salt thereof is represented by the following formula (1). In the formula (1), R1 and R2 may be the same or different and are each independently a hydrogen atom or an alkyl group, R3 is -OR4 or - NHR5, R4 is a sec-butyl group, a tert-butyl group, or an iso-butyl group, and R5 is a sec-butyl group, a tert-butyl group, or an iso-butyl group.

  本发明提供了一种在清除 LO 能力和清除 LOO 能力之间达到良好平衡的化合物。本发明的化合物或其盐由下式（1）表示。在式 (1) 中，R1 和 R2 可以相同或不同，且各自独立地为氢原子或烷基，R3 为-OR4 或-NHR5，R4 为仲丁基、叔丁基或异丁基，R5 为仲丁基、叔丁基或异丁基。
• Method for shortening anti-infective therapy duration in subjects with infection
  申请人：INSTITUTE FOR CLINICAL PHARMACODYNAMICS, INC.

  公开号：US10751303B2

  公开（公告）日：2020-08-25

  Methods of shortening the duration of anti-infective therapy and increasing the effectiveness of anti-infective drugs in subjects with infection are present. The methods are based on altering the replication rate of a pathogen, which makes the pathogen more susceptible to the actions of the anti-infective drug.

  目前已有缩短抗感染治疗时间和提高抗感染药物对感染者疗效的方法。这些方法的基础是改变病原体的复制率，从而使病原体更容易受到抗感染药物的作用。
• Compounds and methods for treating autoimmunity
  申请人：ImmunoMolecular Therapeutics, INC.

  公开号：US11052060B2

  公开（公告）日：2021-07-06

  Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.

  通过调节 DQ8 MHC II 类分子与抗原肽或抗原肽片段的结合，用于治疗、改善或抑制自身免疫性疾病或乳糜泻发展的化合物和组合物。
• AGENTS AND METHODS FOR MODULATING PATHOGEN ACTIVITY
  申请人：Griffith University

  公开号：EP3856196A1

  公开（公告）日：2021-08-04
• METHOD FOR SHORTENING ANTI-INFECTIVE THERAPY DURATION IN SUBJECTS WITH INFECTION
  申请人：INSTITUTE FOR CLINICAL PHARMACODYNAMICS, INC.

  公开号：US20180015055A1

  公开（公告）日：2018-01-18

  Methods of shortening the duration of anti-infective therapy and increasing the effectiveness of anti-infective drugs in subjects with infection are present. The methods are based on altering the replication rate of a pathogen, which makes the pathogen more susceptible to the actions of the anti-infective drug.