Phenol, 4-((2R)-2-aminopropyl)-2-methoxy- | 150200-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenol, 4-((2R)-2-aminopropyl)-2-methoxy-
• 英文别名: 4-[(2R)-2-aminopropyl]-2-methoxyphenol
• CAS: 150200-02-5
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.23
• InChiKey: GPBOYXOSSQEJBH-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS OF TREATING PSYCHOLOGICAL AND BRAIN DISORDERS
  申请人：University of Maryland, Baltimore

  公开号：EP4013403A1

  公开（公告）日：2022-06-22
• US8343928B2
  申请人：——

  公开号：US8343928B2

  公开（公告）日：2013-01-01
• [EN] ANORECTIC EPINEPHRINE DERIVATIVES<br/>[FR] DERIVES D'EPINEPHRINE ANOREXIQUES
  申请人：THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO1994000432A1

  公开（公告）日：1994-01-06

  (EN) The present invention relates to certain novel piperidine-containing, substituted hydroxybenzyl alcohols and their pharmaceutically-acceptable salts (I). The invention further relates to pharmaceutical compositions useful for weigth reduction that alternatively contain as the active ingredient one of these chemical products or other substituted hydroxybenzyl alcohols, such as metaraminol, $g(a)-methylepinephrine, $g(a)-methylnorepinephrine, and N-substituted $g(a)-methylnorepinephrine related compounds of formula (II) where X = (a) and (b). The invention also relates to the use of these pharmaceutical compositions as anorectic agents for mammals.(FR) L'invention concerne certains nouveaux hydroxybenzylalcools substitués contenant de la piperidine et leurs sels pharmaceutiquement acceptable (I). L'invention concerne également des compositions pharmaceutiques de réduction du poids contenant alternativement, comme ingrédient actif, un de ces produits chimiques ou d'autres hydroxybenzylalcools substitués, tels que métaraminol, $g(a)-méthylènepinéphrine, $g(a)-méthylnorépinéphrine, et des composés apparentés à la $g(a)-méthylnorépinéphrine N-substitués de formule (II) où X représente (a) et (b). L'invention concerne également l'utilisation de ces compositions pharmaceutiques comme agents anoréxiques pour mammifères.
• [EN] METHODS OF TREATING PSYCHOLOGICAL AND BRAIN DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES PSYCHOLOGIQUES ET CÉRÉBRAUX
  申请人：UNIV MARYLAND

  公开号：WO2021030571A1

  公开（公告）日：2021-02-18

  Provided herein are methods for preventing or treating a psychological disorder. A serotonin agonist or an agonist of serotonin receptors is administered separately, sequentially or simultaneously in combination with a serotonin receptor 2A antagonist.