4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol | 126861-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
• 英文别名: 4-(2-amino-1-methylimidazo[4,5-b]pyridin-6-yl)phenol
• CAS: 126861-72-1
• 化学式: C₁₃H₁₂N₄O
• 分子量: 240.26
• InChiKey: UGJXOCBVCWTJFP-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

代谢

4'-羟基-PhIP已知的人体代谢物包括PhIP 4'-O-葡萄糖苷酸。

4'-Hydroxy-PhIP has known human metabolites that include PhIP 4'-O-glucuronide.

来源:NORMAN Suspect List Exchange

文献信息

• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.