3,11,19-Tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.12,5.110,13.021,25.09,27.017,26]heptacosa-1(25),2,5,7,9(27),13,15,17(26),21,23-decaene-7,15,23-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 3,11,19-Tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.12,5.110,13.021,25.09,27.017,26]heptacosa-1(25),2,5,7,9(27),13,15,17(26),21,23-decaene-7,15,23-triol
• 英文别名: 3,11,19-tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.12,5.110,13.021,25.09,27.017,26]heptacosa-1(25),2,5,7,9(27),13,15,17(26),21,23-decaene-7,15,23-triol
• 化学式: C₄₂H₂₈O₉
• 分子量: 676.7
• InChiKey: ULEJGXIKBFHUOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  51
• 可旋转键数：
  3
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  153
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• [EN] METHODS AND COMPOSITIONS RELATED TO ENHANCING RETROVIRAL VECTOR ENTRY AND INTEGRATION IN HOST CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS LIÉS À L'AMÉLIORATION DE L'ENTRÉE ET DE L'INTÉGRATION DE VECTEURS RÉTROVIRAUX DANS DES CELLULES HÔTES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2020198320A1

  公开（公告）日：2020-10-01

  The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as a stem cell. The methods involve transducing the host cell with the vector in the presence of a resveratrol oligomer compound (e.g., α-viniferin or caraphenol A or analog compound thereof). Also provided in the invention are kits or pharmaceutical combinations for delivering a therapeutic agent into a target cell with enhanced targeting frequency and payload delivery. The kits or pharmaceutical combinations typically contain a viral vector encoding the therapeutic agent, and a resveratrol oligomer compound.