Cefditorin pivoxil

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: Cefditorin pivoxil
• 英文别名: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 化学式: C₂₅H₂₈N₆O₇S₃
• 分子量: 620.7
• InChiKey: AFZFFLVORLEPPO-ITQWOMERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  257
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• 3 -Alkenylcephem Compounds and Process for Production Thereof
  申请人：Nishioka Yoichi

  公开号：US20080064869A1

  公开（公告）日：2008-03-13

  A 3-alkenylcephem compound of the formula (1) wherein R 1 is benzyl or phenoxymethyl, R 2 , R 3 and R 4 are alike or different and are each a hydrogen atom, C 1-10 alkyl, C 4-8 cycloalkyl or aryl C 1-3 alkyl substituted or unsubstituted with C 1-4 alkyl, R 2 and R 3 , when taken together, form a group —(CH 2 ) l X m (CH 2 ) n — substituted or unsubstituted with C 1-4 alkyl at an optional position, X is an oxygen atom or group —N(R 5 )—, l is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R 5 is a hydrogen atom or C 1-4 alkyl.

  化合物的名称为3-烯丙基头孢菌素，其化学式为（1），其中R1为苄基或苯氧甲基，R2，R3和R4相同或不同，分别为氢原子，C1-10烷基，C4-8环烷基或芳基C1-3烷基，该芳基可以被C1-4烷基取代或未取代，当R2和R3组合在一起时，形成一个基团-（CH2）lXm（ ）n-，在可选位置上用C1-4烷基取代或未取代，X为氧原子或基团-N（R5）-，l为0至3，m为0或1，n为2至4的整数，R5为氢原子或C1-4烷基。
• Process for Production of 3-Alkenylcephem Compounds
  申请人：Nishioka Yoichi

  公开号：US20080033166A1

  公开（公告）日：2008-02-07

  A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.
• US7759483B2
  申请人：——

  公开号：US7759483B2

  公开（公告）日：2010-07-20
• US7893254B2
  申请人：——

  公开号：US7893254B2

  公开（公告）日：2011-02-22