7-deacetoxy-7-oxogedunin | 13072-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 7-deacetoxy-7-oxogedunin
• 英文别名: Deacetoxy-7-oxogedunin；(1R,2R,4S,7S,8S,12S)-7-(furan-3-yl)-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-ene-5,15,19-trione
• CAS: 13072-74-7
• 化学式: C₂₆H₃₀O₆
• 分子量: 438.521
• InChiKey: PMISPNORJONCHB-DKBZVKCESA-N

物化性质

• 熔点：
  260-263 °C
• 沸点：
  588.2±50.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)
• 碰撞截面：
  196.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-deacetoxy-7-oxogedunin 在 platinum(IV) oxide sodium tetrahydroborate 、 氢气 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 0.25h， 生成 7-deacetyl-7-epi-dihydrogedunin
  参考文献：
  名称：

  Kehrli, Anne R. H.; Taylor, David A. H.; Niven, Margaret, Journal of the Chemical Society. Perkin transactions I, 1990, # 7, p. 2057 - 2065

  摘要：

  DOI：

文献信息

• Compositions and methods for neuroprotectin
  申请人：Steiner P. Joseph

  公开号：US20080090897A1

  公开（公告）日：2008-04-17

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• Role of limonoid compounds as neuroprotective agents
  申请人：Steiner Joseph P.

  公开号：US20100056617A1

  公开（公告）日：2010-03-04

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100305068A1

  公开（公告）日：2010-12-02

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.
• US9289412B2
  申请人：——

  公开号：US9289412B2

  公开（公告）日：2016-03-22
• Kehrli, Anne R. H.; Taylor, David A. H.; Niven, Margaret, Journal of the Chemical Society. Perkin transactions I, 1990, # 7, p. 2057 - 2065
  作者：Kehrli, Anne R. H.、Taylor, David A. H.、Niven, Margaret

  DOI：——

  日期：——