2-Amino-6-<2-phenyl-ethylamino>-purin | 59856-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-Amino-6-<2-phenyl-ethylamino>-purin
• 英文别名: N⁶-phenethyl-7(9)H-purine-2,6-diamine；N6-Phenethyl-9H-purine-2,6-diamine；6-N-(2-phenylethyl)-7H-purine-2,6-diamine
• CAS: 59856-85-8
• 化学式: C₁₃H₁₄N₆
• 分子量: 254.294
• InChiKey: VVAAYEZVIGGGED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  92.5
• 氢给体数：
  3
• 氢受体数：
  5

制备方法与用途

NPD9948 是一种竞争性MTH1抑制剂。

反应信息

• 作为产物：
  描述：

  6-硫鸟嘌呤 在 sodium hydroxide 作用下， 生成 2-Amino-6-<2-phenyl-ethylamino>-purin
  参考文献：
  名称：

  Synthesis and Biological Activity of Some 2-Amino-6-(substituted)-purines

  摘要：

  DOI：

  10.1021/ja01513a038

文献信息

• [EN] COMPOUNDS FOR IMPROVING MRNA SPLICING<br/>[FR] COMPOSÉS POUR AMÉLIORER L'ÉPISSAGE DE L'ARNM
  申请人：GEN HOSPITAL CORP

  公开号：WO2016115434A1

  公开（公告）日：2016-07-21

  Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.

  本文提供了一些有助于改善细胞内mRNA剪接的化合物。本文提供的示例化合物有助于改善包含至少一个以核苷酸序列CAA结尾的外显子的基因的mRNA剪接。还提供了制备这些化合物的方法以及治疗中枢神经系统疾病的方法。
• Compounds for improving mRNA splicing
  申请人：The General Hospital Corporation

  公开号：US10676475B2

  公开（公告）日：2020-06-09

  Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.

  本文提供的化合物有助于改善细胞中的 mRNA 剪接。本文提供的示例化合物可用于改善包含至少一个以核苷酸序列 CAA 结尾的外显子的基因中的 mRNA 剪接。还提供了制备这些化合物的方法和治疗中枢神经系统疾病的方法。
• CELLULOSE ACYLATE FILM, RETARDATION FILM, POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：NAGURA MASATO

  公开号：US20110076423A1

  公开（公告）日：2011-03-31

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦A≦2.5, and  (ii) 0.1≦B≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.
• Optical performance humidity dependency improving agent for cellulose acylate film
  申请人：Nagura Masato

  公开号：US20110262661A1

  公开（公告）日：2011-10-27

  An optical performance humidity dependency improving agent for cellulose acylate film, which contains a compound having a nucleic acid base skeleton, is capable of preventing the fluctuation of Re and Rth of the film against the humidity change in usage environments.
• Optical film, retardation film, polarizing plate, and liquid crystal display device
  申请人：Sasada Yasuyuki

  公开号：US20120018685A1

  公开（公告）日：2012-01-26

  An optical film contains a cellulose ester and more than 30% by mass, relative to the cellulose ester, of a condensation product of at least one polyhydric alcohol having an average of 2.01 or more carbon atoms and at least one polybasic acid having an average of 4.10 or more carbon atoms, and at least one of the at least one polyhydric alcohol contains at least three carbon atoms bonded together without being interrupted by any other atom.