17-Desoxy-methason | 382-67-2

• 物质功能分类: 分析化学 - 标准品 - 法医和兽医标准品
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-Desoxy-methason
• 英文别名: 17-Desoxymethason；Topisolon；9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
• CAS: 382-67-2；53798-55-3
• 化学式: C₂₂H₂₉FO₄
• 分子量: 376.468
• InChiKey: VWVSBHGCDBMOOT-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215°C
• 比旋光度：
  D +109° (chloroform)
• 沸点：
  532.3±50.0 °C(Predicted)
• 密度：
  376.46
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• 碰撞截面：
  186.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  5

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用概述：去氧米松在母乳喂养期间尚未进行研究。由于只有大量使用最强效的皮质类固醇才会在母亲体内产生系统性影响，因此短期使用外用皮质类固醇不太可能通过进入母乳而对哺乳婴儿构成风险。然而，最好还是在尽可能小的皮肤面积上使用最弱效的药物。特别是要确保婴儿的皮肤不直接接触已治疗的皮肤区域。只有在乳头或乳晕上使用低效皮质类固醇，因为婴儿可能会直接从皮肤上摄入药物。只有水溶性乳膏或凝胶产品应涂抹在乳房上，因为软膏可能会使婴儿通过舔食接触到高水平的矿物石蜡。如果外用皮质类固醇应用于乳房或乳头区域，应在哺乳前彻底擦除。 ◉ 对哺乳婴儿的影响：将具有相对较高盐皮质激素活性的皮质类固醇（异氟泼尼松醋酸酯）涂在母亲的乳头上，导致她的2个月大哺乳婴儿出现QT间期延长、库欣综合症外貌、严重高血压、生长减少和电解质异常。这位母亲从婴儿出生时起就因乳头疼痛而使用该乳膏。 ◉ 对泌乳和母乳的影响：截至修订日期，未找到相关已发布信息。

◉ Summary of Use during Lactation:Desoximetasone has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area. ◉ Effects in Breastfed Infants:Topical application of a corticosteroid with relatively high mineralocorticoid activity (isofluprednone acetate) to the mother's nipples resulted in prolonged QT interval, cushingoid appearance, severe hypertension, decreased growth and electrolyte abnormalities in her 2-month-old breastfed infant. The mother had used the cream since birth for painful nipples. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S26,S36
• 危险类别码：
  R20/21/22,R40,R36/37/38,R43
• WGK Germany：
  3
• 海关编码：
  2914700090

制备方法与用途

生物活性方面，Desoximetasone（Topicort）是一种皮质类固醇，常用于缓解多种皮肤疾病和皮疹。