Ethyl 6-bromo-4-formyl-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate | 433327-61-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: Ethyl 6-bromo-4-formyl-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
• CAS: 433327-61-8
• 化学式: C₁₈H₁₃BrO₅
• 分子量: 389.202
• InChiKey: WNBGEQYHSUPDGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  苯并噻唑-2-乙腈 、 Ethyl 6-bromo-4-formyl-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Formylation of 5-hydroxybenzofuran derivatives and synthesis of furo-[3,2-f]coumarins based on them*

  摘要：

  The formylation of esters of 5-hydroxy-1-benzofuran-3-carboxylic acid has been studied. The interaction of the synthesized aldehydes with esters of beta-keto acids and hetarylacetonitriles gave furo[3,2-f]coumarin-1-carboxylic acids derivatives.

  DOI：

  10.1007/s10593-011-0886-x
• 作为产物：
  描述：

  乌洛托品 、 Ethyl 6-bromo-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate 在 三氟乙酸 作用下， 以48%的产率得到Ethyl 6-bromo-4-formyl-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
  参考文献：
  名称：

  Formylation of 5-hydroxybenzofuran derivatives and synthesis of furo-[3,2-f]coumarins based on them*

  摘要：

  The formylation of esters of 5-hydroxy-1-benzofuran-3-carboxylic acid has been studied. The interaction of the synthesized aldehydes with esters of beta-keto acids and hetarylacetonitriles gave furo[3,2-f]coumarin-1-carboxylic acids derivatives.

  DOI：

  10.1007/s10593-011-0886-x

文献信息

• Formylation of 5-hydroxybenzofuran derivatives and synthesis of furo-[3,2-f]coumarins based on them*
  作者：M. S. Frasinyuk、S. P. Bondarenko、O. V. Shablykina、V. P. Khilya

  DOI：10.1007/s10593-011-0886-x

  日期：2011.12

  The formylation of esters of 5-hydroxy-1-benzofuran-3-carboxylic acid has been studied. The interaction of the synthesized aldehydes with esters of beta-keto acids and hetarylacetonitriles gave furo[3,2-f]coumarin-1-carboxylic acids derivatives.