Caerulomycin-methylether | 14761-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Caerulomycin-methylether
• 英文别名: 4-methoxy-[2,2']bipyridinyl-6-carbaldehyde O-methyl-oxime；N-methoxy-1-(4-methoxy-6-pyridin-2-ylpyridin-2-yl)methanimine
• CAS: 14761-56-9
• 化学式: C₁₃H₁₃N₃O₂
• 分子量: 243.265
• InChiKey: WOCWELSPPBUMDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  56.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• USE OF BIPYRIDINE COMPOUND 'CAERULOMYCIN A', DERIVATIVES AND ANALOGS THEREOF AS IMMUNOSUPPRESSIVE AGENTS
  申请人：Council of Scientific and Industrial Research

  公开号：EP1942889B1

  公开（公告）日：2015-06-03
• Use of bipyridine compound 'Caerulomycin A' derivatives and analogs thereof as immunosuppressive agents
  申请人：Singla Kumar Arvind

  公开号：US20070078167A1

  公开（公告）日：2007-04-05

  The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4 + T cells, CD8 + T cells and B cells and in the production of IL-4 and IFN-γ and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated from Streptomyces caeruleus and found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.
• US8114895B2
  申请人：——

  公开号：US8114895B2

  公开（公告）日：2012-02-14