acetic acid stilben-2-yl ester | 51924-88-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: acetic acid stilben-2-yl ester
• 英文别名: Essigsaeure-stilben-2-ylester；2-Acetoxy-stilben；Acetoxy stilbene；[2-(2-phenylethenyl)phenyl] acetate
• CAS: 51924-88-0
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: WSPVVKRXXXCPAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetic acid stilben-2-yl ester 在 二硫化碳 、 溴 作用下， 生成 acetic acid-(α,α'-dibromo-bibenzyl-2-yl ester)
  参考文献：
  名称：

  v. Kostanecki; Tambor, Chemische Berichte, 1909, vol. 42, p. 826

  摘要：

  DOI：
• 作为产物：
  描述：

  苯乙烯 、 2-碘苯酚 在 吡啶 、 三乙醇胺 、 palladium diacetate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 acetic acid stilben-2-yl ester
  参考文献：
  名称：

  TRPA1 channels as targets for resveratrol and related stilbenoids

  摘要：

  A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxy-genated stilbenes 6 and 17. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.12.065

文献信息

• NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS
  申请人：DSM IP Assets B.V.

  公开号：EP1984317A1

  公开（公告）日：2008-10-29
• Compositions and Methods for Selectively Activating Human Sirtuins
  申请人：Howitz Konrad T.

  公开号：US20120172340A1

  公开（公告）日：2012-07-05

  Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.
• [EN] NOVEL NUTRACEUTICAL AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS<br/>[FR] COMPOSITIONS NUTRACEUTIQUES ET PHARMACEUTIQUES ATYPIQUES ET LEUR UTILISATION DANS LE TRAITEMENT, LE CO-TRAITEMENT OU LA PREVENTION D'AFFECTIONS INFLAMMATOIRES
  申请人：DSM IP ASSETS BV

  公开号：WO2007093387A1

  公开（公告）日：2007-08-23

  [EN] The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
  [FR] La présente invention concerne des composés aromatiques méthoxylés. Elle a également trait à des compositions atypiques comprenant des composés aromatiques méthoxylés ainsi que l'utilisation de ces compositions comme médicament, en particulier comme médicament pour le traitement, le co-traitement ou la prévention d'affections inflammatoires.
• TRPA1 channels as targets for resveratrol and related stilbenoids
  作者：Marianna Nalli、Giorgio Ortar、Aniello Schiano Moriello、Enrico Morera、Vincenzo Di Marzo、Luciano De Petrocellis

  DOI：10.1016/j.bmcl.2015.12.065

  日期：2016.2

  A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxy-genated stilbenes 6 and 17. (C) 2015 Elsevier Ltd. All rights reserved.
• v. Kostanecki; Tambor, Chemische Berichte, 1909, vol. 42, p. 826
  作者：v. Kostanecki、Tambor

  DOI：——

  日期：——