2-quinazolin-4-ylamino-butyric acid | 55040-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-quinazolin-4-ylamino-butyric acid
• 英文别名: 2-(Quinazolin-4-ylamino)butanoic acid
• CAS: 55040-13-6
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: WVKHAFMZAMKNJB-UHFFFAOYSA-N

物化性质

• 沸点：
  473.4±30.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-quinazolin-4-ylamino-butyric acid 、 溶剂黄146 、 乙酸酐 以56%的产率得到
  参考文献：
  名称：

  SINYAK R. S.; MAZUR I. A.; STEBLYUK P. M.; KOCHERGIN P. M., FARMATSEVT. ZH., 1977, HO 3, 84-85

  摘要：

  DOI：

文献信息

• METHODS FOR TREATING BLOOD DISORDERS
  申请人：Perrine P. Susan

  公开号：US20080075692A1

  公开（公告）日：2008-03-27

  Methods of treating blood disorders are described.

  描述了治疗血液疾病的方法。
• Methods for Treating Blood Disorders
  申请人：Phoenicia Biosciences, Inc.

  公开号：US20140301975A1

  公开（公告）日：2014-10-09

  Methods of treating blood disorders are described.

  描述了治疗血液疾病的方法。
• Methods and compositions for treating viral or virally-induced conditions
  申请人：VIRACTA THERAPEUTICS, INC.

  公开号：US10857152B2

  公开（公告）日：2020-12-08

  Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.

  本文提供了预防和/或治疗病毒病、病毒诱发病和炎症的方法和组合物。这些方法可包括向受试者施用病毒诱导剂与抗病毒剂，以及可选的附加剂。病毒诱导剂可以是口服 HDAC 抑制剂。
• METHODS FOR TREATING VIRAL DISORDERS
  申请人：PERRINE SUSAN P.

  公开号：US20110086869A1

  公开（公告）日：2011-04-14

  Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.
• Methods and Compositions for Treating Viral or Virally-Induced Conditions
  申请人：Berenson Ronald J.

  公开号：US20110245154A1

  公开（公告）日：2011-10-06

  Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.