Dehydro-1,3-dimethyluric acid | 72944-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Dehydro-1,3-dimethyluric acid
• 英文别名: 1,3-Dimethylpurine-2,6,8-trione
• CAS: 72944-43-5
• 化学式: C₇H₆N₄O₃
• 分子量: 194.15
• InChiKey: XNSYLGPLANWBHH-UHFFFAOYSA-N

物化性质

• 沸点：
  277.8±23.0 °C(Predicted)
• 密度：
  1.77±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Dehydro-1,3-dimethyluric acid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以65%的产率得到1,3-二甲基尿酸
  参考文献：
  名称：

  Synthesis of dehydro-1,3-dimethyluric acid

  摘要：

  DOI：

  10.1016/s0040-4039(00)98040-7
• 作为产物：
  描述：

  5-chloro-1,3-dimethyl-5,7-dihydro-3H-purine-2,6,8-trione 195.0~200.0 ℃ 、0.13 Pa 条件下， 以65%的产率得到Dehydro-1,3-dimethyluric acid
  参考文献：
  名称：

  Synthesis of dehydro-1,3-dimethyluric acid

  摘要：

  DOI：

  10.1016/s0040-4039(00)98040-7

文献信息

• Methods for sterilizing tissue
  申请人：——

  公开号：US20030185702A1

  公开（公告）日：2003-10-02

  Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

  本发明公开了用于灭菌组织以减少其中一个或多个活性生物污染物或病原体的水平的方法，例如病毒、细菌（包括细胞内和细胞外细菌，如支原体、尿道支原体、纳米细菌、沙眼衣原体、立克次体）、酵母菌、霉菌、真菌、朊病毒或类似的单独或组合的致病体，以及单细胞或多细胞寄生虫。该方法涉及通过辐照灭菌一个或多个组织。
• Methods for Sterilizing Tissue
  申请人：Burgess Wilson

  公开号：US20110091353A1

  公开（公告）日：2011-04-21

  Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

  本发明揭示了用于灭菌组织以减少其中一个或多个活性生物污染物或病原体水平的方法，例如病毒、细菌（包括细胞内和细胞外细菌，例如支原体、尿道支原体、纳米细菌、沙眼衣原体、立克次体）、酵母菌、霉菌、真菌、朊病毒或类似的单独或组合的代理人，对于TSEs和/或单个或多细胞寄生虫负责。该方法涉及使用辐照灭菌一个或多个组织。
• Theophylline derivatives, antibodies and their preparation from theophylline immunogens, as well as an immuno assay method and reagent means for determining theophylline
  申请人：MILES INC.

  公开号：EP0077896A1

  公开（公告）日：1983-05-04

  Theophylline immunogens, antibodies prepared therefrom, labeled theophylline conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immonoassays for determining theophylline are disclosed. The immunogens comprise theophylline coupled at its 9-position to an immunogenic carrier material. Likewise, the labeled conjugates and synthetic intermediates are 9-position derivatives of theophylline or synthetic precursors thereof. The antibody and labeled reagents are particularly useful in homogeneous nonradioisotopic immunoassays for measuring theophylline in biological fluids such as serum.

  本研究公开了茶碱免疫原、由其制备的抗体、标记的茶碱共轭物、合成中间体，以及在测定茶碱的免疫测定中使用这些抗体和标记的共轭物。 免疫原包括在 9 位与免疫原载体材料偶联的茶碱。 同样，标记的共轭物和合成中间体是茶碱的 9 位衍生物或其合成前体。 抗体和标记试剂特别适用于均相非放射性同位素免疫测定，用于测量血清等生物液体中的茶碱。
• Methods of producing optically active hydroxyesters
  申请人：Nitto Denko Co. Ltd.

  公开号：EP0435293A2

  公开（公告）日：1991-07-03

  This invention relates to methods for producing optically active hydroxyesters and also to methods for producing and purifying optically active five-membered ring lactones. More specifically, the invention provides methods for efficiently, safely, and selectively producing and purifying optically active (R)-hydroxyester (shown by formula 1) and optically active (S)-hydroxyester (shown by formula 2) in high state of purity at ordinary temperature. The invention also relates to application of the inter-convertible optically active (R)-five-membered ring lacton (shown by formula 5). They are intermediates for synthesizing various medicines, agricultural chemicals, and biologically active substances, however especially useful for synthesizing pheromone of a noxious insect, Popillia japonica Newman. (Here,R₁ denotes -C≡C-R₃ or -C=C-R₃; R₂ and R₃ denote straight chain or branched alkyl groups containing 1 to 10 carbon atoms; R₄ denotes alkyl groups, aralkyl groups, or haloalkyl groups containing 1 to 12 carbon atoms and the end group of R₄ may be carboxyl groups; * denotes asymmetricrbon atoms.)

  本发明涉及生产光学活性羟酯的方法，也涉及生产和纯化光学活性五元环内酯的方法。 更具体地说，本发明提供了在常温下高效、安全、选择性地生产和纯化高纯度光学活性（R）-羟酯（如式 1 所示）和光学活性（S）-羟酯（如式 2 所示）的方法。 本发明还涉及可相互转化的光学活性（R）-五元环内酯（如式 5 所示）的应用。 它们是合成各种药物、农药和生物活性物质的中间体，但尤其适用于合成一种有害昆虫 Popillia japonica Newman 的信息素。 (这里，R₁ 表示 -C≡C-R₃ 或 -C=C-R₃；R₂ 和 R₃ 表示含有 1 至 10 个碳原子的直链或支链烷基；R₄ 表示含有 1 至 12 个碳原子的烷基、芳基或卤代烷基，R₄ 的末端基团可以是羧基；* 表示不对称碳原子）。
• Dry solid medium for storage and analysis of genetic material
  申请人：Whatman PLC

  公开号：EP1484111A1

  公开（公告）日：2004-12-08

  The present invention provides a dry solid medium for storing a sample of a genetic material, including RNA and DNA, in a form suitable for subsequent analysis. The dry solid medium of the invention includes a dry solid matrix and a composition including a protein denaturing agent, and a chelating agent. The dry solid medium can further include a component which functions in subsequent analysis of the genetic material using, for example, PCR, reverse transcriptase initiated PCR, LCR, RFLP, or genetic hybridization. A component for subsequent analysis includes, for example, a nucleotide sequences such as a primer, DNA or RNA probe, and a target sequence stabilizer. The dry solid medium can also include a retaining agent to enhance retention of a component for subsequent analysis. The invention also provides methods for using the dry solid medium of the invention. The dry solid media and methods of use thereof are particularly suited for use in automated systems.

  本发明提供了一种干固体介质，用于以适合后续分析的形式储存遗传物质样本，包括 RNA 和 DNA。本发明的干固体介质包括干固体基质和一种包括蛋白质变性剂和螯合剂的组合物。干固体培养基还可以包括一种成分，这种成分可用于对遗传物质进行后续分析，例如使用 PCR、逆转录酶引发的 PCR、LCR、RFLP 或基因杂交。用于后续分析的成分包括引物、DNA 或 RNA 探针等核苷酸序列和目标序列稳定剂。干燥固体培养基还可以包括一种保留剂，以提高用于后续分析的成分的保留率。本发明还提供了使用本发明干固体培养基的方法。干固体培养基及其使用方法特别适合在自动化系统中使用。