tropacocaine | 16052-34-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tropacocaine
• 英文别名: Benzoyltropin；O-Benzoyltropin；Tropinbenzoat；Benzoyltropein；(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) benzoate
• CAS: 16052-34-9
• 化学式: C₁₅H₁₉NO₂
• 分子量: 245.321
• InChiKey: XQJMXPAEFMWDOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  镉 、 potassium bromide 、 tropacocaine 以 水 为溶剂， 生成 tropacocainium tetrabromocadmate
  参考文献：
  名称：

  White, E. P., Journal of the American Pharmaceutical Association (1912), 1941, vol. 30, p. 156 - 161

  摘要：

  DOI：

文献信息

• [EN] THERAPEUTIC ACRYLATES AS ENHANCED MEDICAL ADHESIVES<br/>[FR] ACRYLATES THÉRAPEUTIQUES UTILES EN TANT QU'ADHÉSIFS MÉDICAUX AMÉLIORÉS
  申请人：UNIV CARNEGIE MELLON

  公开号：WO2018052936A1

  公开（公告）日：2018-03-22

  Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone cement also are provided along with uses for the compositions.

  本文提供了作为医用粘合剂有用的治疗丙烯酸酯化合物，包括与甲基丙烯酸酯或氰丙烯酸酯基团共价连接的治疗剂。此外还提供了粘合剂组合物和套件，如液体缝合线和骨水泥，以及这些组合物的用途。
• NOVEL COMPOUNDS
  申请人：Peters Dan

  公开号：US20120004257A1

  公开（公告）日：2012-01-05

  The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本申请公开了新颖的8-aza-bicyclo[3.2.1]oct-3-yloxy)chromen-2-one衍生物及其作为单胺神经递质再摄取抑制剂的用途。在其他方面，该申请还公开了这些化合物在治疗方法中的用途，以及包括本发明化合物的药物组合物。
• MEDICAL ADHESIVE FOR SURGERY
  申请人：Heckroth Heike

  公开号：US20110245351A1

  公开（公告）日：2011-10-06

  The invention relates to novel rapidly-curing adhesives made from hydrophilic polyisocyanate prepolymers for application in surgery.

  该发明涉及一种用于手术中的新型快速固化胶粘剂，该胶粘剂由亲水性聚异氰酸酯预聚物制成。
• Topical anesthesia compositions
  申请人：——

  公开号：US20040072792A1

  公开（公告）日：2004-04-15

  A composition for local anesthesia which comprises a local anesthetic as an active ingredient and an agent for maintaining anesthetic action selected from the group consisting of acidic mucopolysaccharides such as sodium chondroitin sulfate and cellulose derivatives such as hydroxypropylmethylcellulose, and does not contain catecholamines, which has durability of anesthetic action suitable for minor dental operations such as tooth extraction, and can be used as a safe composition for local anesthesia used for oral surgery or dental treatment.

  一种用于局部麻醉的组合物，其包括局部麻醉剂作为活性成分，以及用于维持麻醉作用的剂选自包括酸性黏多糖，如硫酸软骨素钠和纤维素衍生物，如羟丙基甲基纤维素，并且不含儿茶酚胺，具有适合于轻微的牙科手术，例如拔牙的麻醉作用的持久性，并且可以用作用于口腔手术或牙科治疗的安全局部麻醉组合物。
• Composition for local anesthesia
  申请人：Haraguchi Mitsuhiro

  公开号：US20060189572A1

  公开（公告）日：2006-08-24

  A composition for local anesthesia which comprises a local anesthetic as an active ingredient and an agent for maintaining anesthetic action selected from the group consisting of acidic mucopolysaccharides such as sodium chondroitin sulfate and cellulose derivatives such as hydroxypropylmethylcellulose, and does not contain catecholamines, which has durability of anesthetic action suitable for minor dental operations such as tooth extraction, and can be used as a safe composition for local anesthesia used for oral surgery or dental treatment.

  一种用于局部麻醉的组合物，其包括局部麻醉剂作为活性成分和维持麻醉作用的药剂，所述药剂选自包括酸性粘多糖如硫酸软骨素钠和纤维素衍生物如羟丙基甲基纤维素的群体，不含儿茶酚胺，具有适用于小型牙科手术（如拔牙）的麻醉作用持久性，并可用作口腔外科或牙科治疗中使用的安全局部麻醉组合物。

表征谱图