O-tosyl-N-α,α-bis(ethoxycarbonyl)-β-methoxyethylhydroxylamine | 131285-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-tosyl-N-α,α-bis(ethoxycarbonyl)-β-methoxyethylhydroxylamine
• 英文别名: Methoxymethyl(tosyloxyamino)malonic acid diethyl ester；diethyl 2-(methoxymethyl)-2-[(4-methylphenyl)sulfonyloxyamino]propanedioate
• CAS: 131285-36-4
• 化学式: C₁₆H₂₃NO₈S
• 分子量: 389.427
• InChiKey: MVBQNLPCXLNORP-UHFFFAOYSA-N

物化性质

• 沸点：
  500.5±60.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-tosyloxy-5,5-bis(ethoxycarbonyl)-Δ²-1,2,3-triazoline 在 甲醇 作用下， 反应 5.0h， 以61%的产率得到O-tosyl-N-α,α-bis(ethoxycarbonyl)-β-methoxyethylhydroxylamine
  参考文献：
  名称：

  Geminal systems. 50. Solvolysis of 1-tosyloxy-?2-1,2,3-triazoline-5,5-dicarboxylate esters and the structure of the solvolysis product, O-tosyl-N-?,?-bis(ethoxycarbonyl)-?-methoxyethylhydroxylamine

  摘要：

  Solvolysis of 1-tosyloxy-open triangle2-1,2,3-triazoline-5,5-dicarboxylic acid esters (1) occurs via elimination of N2 and leads predominantly to N-beta-hydroxylethyl-O-tosylhydroxylamines (II), whose structure was determined unequivocally by x-ray structural analysis. The mechanism of solvolysis of triazolines (I) is discussed, along with the structural characteristics and stabilization factors of the O-tosylhydroxylamine products (II).

  DOI：

  10.1007/bf00961496

文献信息

• Geminal systems. 50. Solvolysis of 1-tosyloxy-?2-1,2,3-triazoline-5,5-dicarboxylate esters and the structure of the solvolysis product, O-tosyl-N-?,?-bis(ethoxycarbonyl)-?-methoxyethylhydroxylamine
  作者：G. V. Shustov、A. B. Zolotoi、P. N. Belov、S. V. Konovalikhin、L. O. Atovmyan、V. N. Voznesenskii、R. G. Kostyanovskii

  DOI：10.1007/bf00961496

  日期：1990.8

  Solvolysis of 1-tosyloxy-open triangle2-1,2,3-triazoline-5,5-dicarboxylic acid esters (1) occurs via elimination of N2 and leads predominantly to N-beta-hydroxylethyl-O-tosylhydroxylamines (II), whose structure was determined unequivocally by x-ray structural analysis. The mechanism of solvolysis of triazolines (I) is discussed, along with the structural characteristics and stabilization factors of the O-tosylhydroxylamine products (II).