Benzoyl-arginin-ethylester | 5722-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoyl-arginin-ethylester
• 英文别名: Ethyl 5-{[amino(imino)methyl]amino}-2-(benzoylamino)pentanoate；ethyl 2-benzamido-5-(diaminomethylideneamino)pentanoate
• CAS: 5722-01-0
• 化学式: C₁₅H₂₂N₄O₃
• mdl: MFCD03407280
• 分子量: 306.365
• InChiKey: YQDHCCVUYCIGSW-UHFFFAOYSA-N

物化性质

• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

文献信息

• Fluorescence polarization assay for macromolecular hydrolases.
  申请人：ABBOTT LABORATORIES

  公开号：EP0194472A2

  公开（公告）日：1986-09-17

  A fluorescence polarization assay for determining the presence and/or amount of macromolecular hydrolases such as polysaccharide hydrolases, amylase, trypsin, proteases and lipases is disclosed. The disclosure provides reagents, processes for making the reagents useful in the assay and processes for conducting the assay. The assay involves the use of a substrate capable of being cleaved by the macromolecular hydrolase being determined, wherein the substrate is coupled to a fluorophore.

  本发明公开了一种荧光偏振测定法，用于确定多糖水解酶、淀粉酶、胰蛋白酶、蛋白酶和脂肪酶等大分子水解酶的存在和/或数量。本发明提供了试剂、试剂的制备方法和试剂的检测方法。该检测涉及使用能够被正在测定的大分子水解酶裂解的底物，其中底物与荧光团耦合。
• Filler for measuring enzyme activity, column packed with the filler, and method of measuring enzyme activity using the column
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP0329190A2

  公开（公告）日：1989-08-23

  Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a support and a substrate that can be recognized by the enzyme, which is immobilized on the support, and measuring the amount of the obtained decomposition product of the substrate.

  酶的活性是通过将需要测量其活性的酶导入一个由空心管组成的柱中，空心管中填充物包括支撑物和可被固定在支撑物上的酶识别的底物，然后测量所获得的底物分解产物的量，从而快速、高精度地测量酶的活性。
• Method for assaying activity of prophenoloxidase activating enzyme and application thereof
  申请人：Wako Pure Chemical Industies, Ltd.

  公开号：EP0657546A1

  公开（公告）日：1995-06-14

  A method for assaying an activity of a prophenoloxidase activating enzyme (PPAE), comprising assaying at least X-Arg or Y produced upon contact of the PPAE with a peptide chain of the formula         X - Arg - Y wherein X is an optionally labeled amino acid residue or peptide residue, having an optionally protected α-amino group or N-terminal, provided that the amino acid residue adjoining Arg is not Gly or Ala, and Y is an organic residue capable of binding to a carboxyl group of Arg by acid amide bonding or ester bonding, or an optionally labeled amino acid residue or peptide residue, having an optionally protected α-carboxyl group or C-terminal, the peptide chain capable of being hydrolyzed into X-Arg and Y by a PPAE derived from an insect. According to the present invention, PPAE activity can be quantitatively assayed with precision and a highly precise method for determining β-1,3-glucan and/or peptidoglycan, wherein said PPAE activity is used as an index, can be provided. In addition, the present invention enables detection of fungi and bacteria without multiplication by culture, which makes early diagnosis of microbial infections possible. The present invention is applicable to a wide range of use such as tests for microbial contamination of water and food, safety tests of therapeutic agents such as antibiotics and injectable preparations, etc.

  一种检测丙醇氧化酶活化酶（PPAE）活性的方法，包括检测 PPAE 与式中肽链接触时产生的至少 X-Arg 或 Y。 X - Arg - Y 其中 X 是可选择标记的氨基酸残基或肽残基，具有可选择保护的 α-氨基或 N-末端，条件是与 Arg 相邻的氨基酸残基不是 Gly 或 Ala，Y 是可通过酸酰胺键或酯键与 Arg 的羧基结合的有机残基、或可选择标记的氨基酸残基或肽残基，具有可选择保护的 α-羧基或 C-末端，该肽链能够被来源于昆虫的 PPAE 水解为 X-Arg 和 Y。根据本发明，可以对 PPAE 活性进行精确的定量检测，并提供一种高精度的方法来测定 β-1,3-葡聚糖和/或肽聚糖，其中所述 PPAE 活性被用作一种指标。此外，本发明无需通过培养繁殖即可检测真菌和细菌，这使得早期诊断微生物感染成为可能。本发明适用范围广泛，如检测水和食品的微生物污染、抗生素和注射制剂等治疗药物的安全性检测等。
• MEDICINAL COMPOSITIONS FOR IMPROVING ORAL ABSORPTION
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1466626A1

  公开（公告）日：2004-10-13

  The present invention relates to an agent for inhibiting decomposition of a biologically active peptide by a digestive enzyme, which is aminoalkyl methacrylate coplolymer E as an effective ingredient, and an agent for reducing viscosity of the gastrointestinal mucosa and mucous layers distributed over this mucosa. The present invention relates to a method for inhibiting decomposition of a biologically active peptide by a digestive enzyme, or a method for reducing viscosity of the gastrointestinal mucosa and/or mucous layers distributed over the mucosa, by administration of aminoalkyl methacrylate copolymer E. Furthermore, the present invention relates to a pharmaceutical composition for oral use with improved absorption, which comprises a biologically active peptide and aminoalkyl methacrylate copolymer E. Excellent oral absorption of a biologically active peptide that were considered difficult to absorb by oral administration in the past, can be realized based on the ability to inhibit decomposition of a biologically active peptide, the ability to reduce viscosity of the gastrointestinal mucosa and/or mucous layers distributed over this mucosa, and the ability to improve permeability of a biologically active peptide in the gastrointestinal mucosa and/or mucous layers of the pharmaceutical composition of the present invention.

  本发明涉及一种抑制消化酶分解生物活性肽的制剂，其有效成分为氨基烷基甲基丙烯酸酯共聚物E，以及一种降低胃肠道粘膜和分布在该粘膜上的粘液层粘度的制剂。本发明涉及一种通过服用甲基丙烯酸氨基烷基酯共聚物 E 来抑制消化酶分解生物活性肽的方法，或降低胃肠道粘膜和/或分布在粘膜上的粘膜层粘度的方法。此外，本发明还涉及一种具有更好吸收性的口服药物组合物，它由生物活性肽和甲基丙烯酸氨基烷基酯共聚物 E 组成。本发明的药物组合物能够抑制生物活性肽的分解，能够降低胃肠道粘膜和/或分布在胃肠道粘膜上的粘膜层的粘度，能够改善生物活性肽在胃肠道粘膜和/或粘膜层中的渗透性，因此能够实现以往认为难以通过口服吸收的生物活性肽的良好口服吸收。
• NOVEL ANTI-PAD2 ANTIBODY
  申请人：Pharma Foods International Co., Ltd.

  公开号：EP3816289A1

  公开（公告）日：2021-05-05

  To obtain an anti-PAD2 antibody having excellent PAD2 inhibitory activity. Provided is an anti-PAD2 antibody that specifically binds to positions 341 to 357 of PAD2. Also provided is an anti-PAD2 antibody that specifically binds to a peptide consisting of an amino acid sequence set forth in SEQ ID NO: 1.

  获得一种具有极佳 PAD2 抑制活性的抗 PAD2 抗体。本发明提供了一种抗 PAD2 抗体，它能与 PAD2 的 341 至 357 位特异性结合。还提供了一种抗 PAD2 抗体，它能与由 SEQ ID NO: 1 所列氨基酸序列组成的肽特异性结合。