Thalicarpin | 1134674-59-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: Thalicarpin
• 英文别名: 9-[2-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-4,5-dimethoxy-phenoxy]-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline；Thaliblastine；9-[2-[(6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]-4,5-dimethoxyphenoxy]-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
• CAS: 1134674-59-1
• 化学式: C₄₁H₄₈N₂O₈
• 分子量: 696.841
• InChiKey: ZCTJIMXXSXQXRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  51
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU SARS-COV 2
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2021225767A1

  公开（公告）日：2021-11-11

  Disclosed herein are methods that are useful for treating a subject who has a pathogenic infection, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); reducing the likelihood of the subject from being infected by a pathogen; and for reducing the transmission of a pathogen from a subject to others. The methods utilize a compound disclosed in Table 1 or Table 4 herein, optionally in combination with an additional agent such as an anti-infective agent.