5-acetyl-2,3-dihydroxy-6-methyl-9-oxo-7-(3,6,7-trihydroxy-4-oxo-2H-chromene-3-carbonyl)xanthene-1-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: 5-acetyl-2,3-dihydroxy-6-methyl-9-oxo-7-(3,6,7-trihydroxy-4-oxo-2H-chromene-3-carbonyl)xanthene-1-carboxylic acid
• 化学式: C₂₇H₁₈O₁₃
• 分子量: 550.4
• InChiKey: ZFYVQYPQSSHPTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  40
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  225
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS
  申请人：CASALNUOVO ALBERT LOREN

  公开号：US20080306259A1

  公开（公告）日：2008-12-11

  The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxidant selected from oxygen, hydrogen peroxide, peracids or alkyl hydropetoxides in the presence of a zirconium complex, wherein R 1 , R 2 and R 3 are as defined in the disclosure. This invention also pertains to zirconium complexes useful in this procedure comprising zirconium and a ligand of Formula III or its enantiomer wherein J, R 6 and n are as defined in the disclosure. This invention further pertains to a compound of Formula III or its enantiomer.

  本发明涉及一种制备公式I化合物的方法，该化合物是在羟基化中心处无手性、外消旋或对映富集的，所述方法包括将公式II化合物与氧、过氧化氢、过酸或烷基过氧化物等氧化剂在锆配合物的存在下接触，其中R1、R2和R3如本文所定义。本发明还涉及在该过程中有用的锆配合物，其包括锆和公式III配体或其对映体，其中J、R6和n如本文所定义。本发明还涉及公式III或其对映体的化合物。
• Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts
  申请人：Casalnuovo Albert Loren

  公开号：US20100185014A1

  公开（公告）日：2010-07-22

  The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxidant selected from oxygen, hydrogen peroxide, peracids or alkyl hydroperoxides in the presence of a zirconium complex, wherein R 1 , R 2 and R 3 are as defined in the disclosure. This invention also pertains to zirconium complexes useful in this procedure comprising zirconium and a ligand of Formula III or its enantiomer wherein J, R 6 and n are as defined in the disclosure. This invention further pertains to a compound of Formula III or its enantiomer.

  本发明涉及一种制备公式I化合物的方法，该化合物是在*处的羟基化中心上是无手性、外消旋或对映富集的，包括将公式II化合物与氧气、过氧化氢、过酸或烷基过氧化物等氧化剂在锆配合物存在下接触，其中R1、R2和R3如本文所定义。本发明还涉及在该过程中有用的锆配合物，包括锆和公式III或其对映体的配体，其中J、R6和n如本文所定义。本发明还涉及公式III或其对映体的化合物。
• Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
  申请人：Kimura Toru

  公开号：US20070015820A1

  公开（公告）日：2007-01-18

  To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
• US7244761B2
  申请人：——

  公开号：US7244761B2

  公开（公告）日：2007-07-17
• US7317038B2
  申请人：——

  公开号：US7317038B2

  公开（公告）日：2008-01-08