m-3M3FBS | 9013-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: m-3M3FBS
• 英文别名: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
• CAS: 9013-93-8
• 化学式: C₁₆H₁₆F₃NO₂S
• mdl: MFCD00095824
• 分子量: 343.4
• InChiKey: ZIIUUSVHCHPIQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHOD FOR ANALYZING FUNCTIONAL SUBUNIT PAIR GENE OF T CELL RECEPTOR AND B CELL RECEPTOR
  申请人：Repertoire Genesis Incorporation

  公开号：EP3842550A1

  公开（公告）日：2021-06-30

  The present disclosure provides a method for analyzing a functional subunit pair gene of a T cell receptor (TCR) or a B cell receptor (BCR). The present disclosure provides a method comprising: (1) a step for providing a nucleic acid sample containing a nucleic acid of a TCR or BCR from a cell expressing an activated TCR or BCR; (2) a step for determining the nucleic acid sequence of the functional pair gene of the TCR or the BCR; and (3) a step for calculating the frequency of appearance of each gene and combinations thereof on the basis of the determined nucleic sequences, and identifying a functional subunit pair gene of the TCR or the BCR.

  本公开提供了一种分析 T 细胞受体（TCR）或 B 细胞受体（BCR）功能亚基对基因的方法。本公开提供的方法包括：(1) 从表达活化的 TCR 或 BCR 的细胞中提供含有 TCR 或 BCR 核酸的核酸样本的步骤；(2) 确定 TCR 或 BCR 的功能亚单位对基因的核酸序列的步骤；(3) 根据确定的核酸序列计算各基因及其组合的出现频率，并确定 TCR 或 BCR 的功能亚单位对基因的步骤。
• Renilla based biosensors for monitoring biomolecule localization and trafficking in cells
  申请人：The Royal Institution for the Advancement of Learning/McGill University

  公开号：US10584159B2

  公开（公告）日：2020-03-10

  Bioluminescence resonance energy transfer (BRET) biosensors for assessing the intracellular localization, internalization and trafficking into cellular compartments of proteins such as receptors, and other biomolecules such as second messengers, are disclosed. These biosensors, which are dependent on the concentration/density of the BRET donor and acceptor in cellular compartments rather that specific protein-protein interactions, use a Renilla GFP/Luc BRET pair, which allows the robust and reproducible monitoring of protein trafficking/localization, with a sensitivity compatible with high-throughput screening (HTS). The use of these biosensors for various applications, including assessing/monitoring protein endocytosis, recycling and intracellular trafficking, receptor maturation/rescue by pharmacological chaperones, various endocytosis/exocytosis processes, activation/inhibition, as well as biomolecule concentration/density in different cellular compartments, is also disclosed.

  本发明公开了生物发光共振能量转移（BRET）生物传感器，用于评估蛋白质（如受体）和其他生物大分子（如第二信使）在细胞内的定位、内化和向细胞区室的迁移。这些生物传感器依赖于细胞区室中 BRET 供体和受体的浓度/密度，而不是特定的蛋白质-蛋白质相互作用，它们使用 Renilla GFP/Luc BRET 对，可对蛋白质的迁移/定位进行稳健、可重复的监测，灵敏度与高通量筛选 (HTS) 兼容。还披露了这些生物传感器在各种应用中的使用情况，包括评估/监测蛋白质的内吞、循环和细胞内贩运、受体的成熟/药理伴侣的拯救、各种内吞/外吞过程、激活/抑制以及生物分子在不同细胞区室中的浓度/密度。
• Compound that directly stimulates phospholipase C activity
  申请人：——

  公开号：US20040220268A1

  公开（公告）日：2004-11-04

  The present application discloses a method for activating phospholipase C (PLC) activity in a cell by contacting a cell that contains phospholipase C with a compound of Formula I.

  本申请公开了一种激活细胞中磷脂酶 C (PLC) 活性的方法，方法是将含有磷脂酶 C 的细胞与式 I 化合物接触。
• BIOSENSORS FOR MONITORING BIOMOLECULE LOCALIZATION AND TRAFFICKING IN CELLS
  申请人：The Royal Institution for the Advancement of Learning / McGill University

  公开号：EP3194960A1

  公开（公告）日：2017-07-26
• SCREENING FOR COMPOUNDS HAVING IMMUNOSUPPRESSANT ACTIVITY BY TESTING IMPACT ON LEUKOCYTE-SPECIFIC CALCIUM FLUXES
  申请人：Pieters Jean

  公开号：US20110123994A1

  公开（公告）日：2011-05-26

  The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca 2+ flux in coronin 1 expressing cells and/or in coronin 1 negative cells. A candidate compound is identified as having immunosuppressant activity if it blocks the Ca 2+ flux specifically in coronin 1 expressing cells. Further described are upstream assays wherein the impact of a candidate compound on coronin 1 trimerization is measured, and downstream assays wherein the impact of a candidate compound on diacyl glycerol (DAG) generation, phosphatidylinositol-4,5-biphosphate (PIP 2 ) levels and/or inositol-1,4,5-triphosphate (InsP 3 ) generation or on nuclear factor of activated T cells (NFAT) nuclear localization is determined.