rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride | 857681-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride
• 英文别名: 4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one hydrochloride；4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one;hydrochloride
• CAS: 857681-22-2
• 化学式: C₁₄H₁₇FN₂O*ClH
• 分子量: 284.761
• InChiKey: LRGNCHKUJIWUGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride 在 N,N-二异丙基乙胺 、 三氟乙酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 hexanes 、 二氯甲烷 、 水 、 乙酸乙酯 、 异丙醇 为溶剂， 反应 1.08h， 生成 (S)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one
  参考文献：
  名称：

  ISOFORM SELECTIVE PHOSPHOLIPASE D INHIBITORS

  摘要：

  本发明公开了选择性异构体磷脂酶D抑制剂。在一方面，所公开的化合物可以具有公式（I）所表示的结构。还公开了制备和使用该化合物的方法。还公开了包含该化合物的药物组合物和试剂盒。本摘要旨在作为特定艺术领域搜索的扫描工具，不意味着对本发明的限制。

  公开号：

  US20120214832A1

文献信息

• Diaza-spiropiperidine derivatives
  申请人：Jolidon Synese

  公开号：US20050154000A1

  公开（公告）日：2005-07-14

  The present invention relates to compounds of formula wherein A—B, R 1 , R 2 , R 3 , R 4 , and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the treatment of neurological and neuropsychiatric disorders.

  本发明涉及以下式的化合物 其中 A—B，R 1 ，R 2 ， R 3 ，R 4 和n如本文所定义；以及其药学上可接受的盐。 式I的化合物可用于治疗神经系统和神经精神疾病。
• Isoform selective phospholipase D inhibitors
  申请人：Brown H. Alex

  公开号：US09127005B2

  公开（公告）日：2015-09-08

  Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及一种选择性的异构型磷脂酶D抑制剂。在一方面，所披露的化合物可以具有以下式子（I）所表示的结构：还披露了制备和使用这些化合物的方法。此外，还披露了包含这些化合物的药物组合物和试剂盒。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• DIAZA-SPIROPIPERIDINE DERIVATIVES AS INHIBITORS OF GLYCINE TRANSPORTER 1 AND GLYCINE TRANSPORTER 2
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1716147B1

  公开（公告）日：2007-11-14
• US9127005B2
  申请人：——

  公开号：US9127005B2

  公开（公告）日：2015-09-08
• [EN] DIAZA-SPIROPIPERIDINE DERIVATIVES AS INHIBITORS OF TRANSPORTER 1 AND GLYCINE TRANSPORTER 2<br/>[FR] DERIVES DE LA DIAZA-SPIROPIPERIDINE UTILISES COMME INHIBITEURS DU TRANSPORTEUR 1 ET DU TRANSPORTEUR DE LA GLYCINE 2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005068462A1

  公开（公告）日：2005-07-28

  The present invention relates to compounds of formula (I) wherein A-B is CH2-CH2, -CH2-O-, O-CH2, CH2-S, -S-CH2-, CH2-C(O)-, C(O)-CH2-, .-N(R4)-CH2- or -CH2-N(R4)-; R1 is lower alkyl, lower alkenyl, cycloalkyl, or is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, cyano, lower alkyl, CF3, OCF3 or lower alkoxy, or is heteroaryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, CF3 or lower alkoxy; R2 is lower alkyl, cycloalkyl, or is aryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, CF3, lower alkoxy, or is heteroaryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, CF3, lower alkoxy, or is heteroaryl, optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, CF3, or lower alkoxy; R3 is hydrogen, lower alkyl or benzyl; R4 is hydrogen or benzyl; n is 0, 1 or 2; and to pharmaceutically available salts thereof. The compounds of formula I may be used in the treatment of neurological and neuropsychiatric disorders.