摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

N'-(5-bromo-2-hydroxybenzylidene)-2-(4-methoxyphenyl)acetyl hydrazide | 41377-40-6

中文名称
——
中文别名
——
英文名称
N'-(5-bromo-2-hydroxybenzylidene)-2-(4-methoxyphenyl)acetyl hydrazide
英文别名
N’-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide;N′-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide;H2BMH;N'-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide;4-Methoxy-benzoesaeure-5-bromsalicyliden-hydrazon;N-[(5-bromo-2-hydroxyphenyl)methylideneamino]-4-methoxybenzamide
N'-(5-bromo-2-hydroxybenzylidene)-2-(4-methoxyphenyl)acetyl hydrazide化学式
CAS
41377-40-6
化学式
C15H13BrN2O3
mdl
MFCD00492229
分子量
349.184
InChiKey
TZGODVDLHYAZGQ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.1
  • 重原子数:
    21
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.07
  • 拓扑面积:
    70.9
  • 氢给体数:
    2
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    钒与氨基酸硫代苯胺衍生物的络合物:抑制人类磷酸酶以及在各种代谢紊乱细胞模型中的特异性
    摘要:
    本文描述了新型 ONS 型钒 (V) 与氨基酸硫代苯胺衍生物配合物的合成和特性。他们表现出在亚微摩尔范围内对人类蛋白酪氨酸磷酸酶(PTP1B、LAR、SHP1 和 SHP2)的抑制作用,以及对非酪氨酸磷酸酶(CDC25A 和 PPA2)的抑制作用,与​​双(麦芽糖)氧化钒(IV)类似。 BMOV)。 ONS 复合物增加了 [14C]-脱氧-D-葡萄糖向 C2C12 肌细胞的转运,其中之一 VC070 也增强了 3T3-L1 脂肪细胞中的这种转运。这些复合物抑制肝细胞 HepG2 中的糖异生,但在使用相同细胞的非酒精性脂肪肝疾病模型中,它们都没有减少脂质积累。与所测试的以5-溴水杨醛和取代苯甲酰肼为席夫碱配体成分的ONO型钒配合物相比,ONS配合物对蛋白酪氨酸磷酸酶具有更强的抑制作用,但ONO配合物在细胞模型中总体上表现出更大的活性。此外,两组的大多数活性复合物均表现出比 VOSO4 和 BMOV
    DOI:
    10.3390/ph17020229
  • 作为产物:
    参考文献:
    名称:
    钒与氨基酸硫代苯胺衍生物的络合物:抑制人类磷酸酶以及在各种代谢紊乱细胞模型中的特异性
    摘要:
    本文描述了新型 ONS 型钒 (V) 与氨基酸硫代苯胺衍生物配合物的合成和特性。他们表现出在亚微摩尔范围内对人类蛋白酪氨酸磷酸酶(PTP1B、LAR、SHP1 和 SHP2)的抑制作用,以及对非酪氨酸磷酸酶(CDC25A 和 PPA2)的抑制作用,与​​双(麦芽糖)氧化钒(IV)类似。 BMOV)。 ONS 复合物增加了 [14C]-脱氧-D-葡萄糖向 C2C12 肌细胞的转运,其中之一 VC070 也增强了 3T3-L1 脂肪细胞中的这种转运。这些复合物抑制肝细胞 HepG2 中的糖异生,但在使用相同细胞的非酒精性脂肪肝疾病模型中,它们都没有减少脂质积累。与所测试的以5-溴水杨醛和取代苯甲酰肼为席夫碱配体成分的ONO型钒配合物相比,ONS配合物对蛋白酪氨酸磷酸酶具有更强的抑制作用,但ONO配合物在细胞模型中总体上表现出更大的活性。此外,两组的大多数活性复合物均表现出比 VOSO4 和 BMOV
    DOI:
    10.3390/ph17020229
点击查看最新优质反应信息

文献信息

  • Benzaldehyde Schiff bases regulation to the metabolism, hemolysis, and virulence genes expression in vitro and their structure–microbicidal activity relationship
    作者:Lei Xia、Yu-Fen Xia、Li-Rong Huang、Xiao Xiao、Hua-Yong Lou、Tang-Jingjun Liu、Wei-Dong Pan、Heng Luo
    DOI:10.1016/j.ejmech.2015.04.042
    日期:2015.6
    There is an urgent need to develop new antibacterial agents because of multidrug resistance by bacteria and fungi. Schiff bases (aldehyde or ketone-like compounds) exhibit intense antibacterial characteristics, and are therefore, promising candidates as antibacterial agents. To investigate the mechanism of action of newly designed benzaldehyde Schiff bases, a series of high-yielding benzaldehyde Schiff bases were synthesized, and their structures were determined by NMR and MS spectra data. The structure microbicidal activity relationship of derivatives was investigated, and the antibacterial mechanisms were investigated by gene assays for the expression of functional genes in vitro using Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The active compounds were selective for certain active groups. The polar substitution of the R-2 group of the amino acids in the Schiff bases, affected the antibacterial activity against E. coli and S. aureus; specific active group at the R-3 or R-4 groups of the acylhydrazone Schiff bases could improve their inhibitory activity against these three tested organisms. The antibacterial mechanism of the active benzaldehyde Schiff bases appeared to regulate the expression of metabolism-associated genes in E. coli, hemolysis-associated genes in B. subtilis, and key virulence genes in S. aureus. Some benzaldehyde Schiff bases were bactericidal to all the three strains and appeared to regulate gene expression associated with metabolism, hemolysis, and virulence, in vitro. The newly designed benzaldehyde Schiff bases possessed unique antibacterial activity and might be potentially useful for prophylactic or therapeutic intervention of bacterial infections. (C) 2015 Published by Elsevier Masson SAS.
  • Synthesis, Crystal Structures and Catalytic Property of Oxidovanadium(V) Complexes with Similar Aroylhydrazones
    作者:Min Liang、Nan Sun、Dong-Hui Zou
    DOI:10.17344/acsi.2018.4625
    日期:——
    A pair of new oxidovanadium(V) complexes, [(VOLL)-L-1]center dot EtOH (1) and [(VOLL)-L-2]center dot EtOH (2) (L = acetohydroxamate), derived from the aroylhydrazones N'-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H2L1 ) and N'-(5-bro-mo-2-hydroxybenzylidene)-4-methylbenzohydrazide (H2L2), have been prepared and characterized by elemental analyses, FT-IR, H-1 and C-13 NMR spectroscopy and single-crystal structural X-ray diffraction. The complexes have octahedral structures in which the aroylhydrazone ligands behave as binegative donors. Single-crystal structure analyses reveal that the V centers are coordinated by the donor atoms of the aroylhydrazone ligands, the acetohydroxamate ligands and the wddo groups. Crystal structures of the complexes are stabilized by hydrogen bonds. The complexes function as effective olefin epoxidation catalysts.
  • Syntheses and structures of <i>N’</i>-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide and its dioxomolybdenum(VI) complex with catalytic epoxidation property
    作者:Yong-Ming Cui、Yan Wang、Ying-Jie Cai、Xue-Jun Long、Wu Chen
    DOI:10.1080/00958972.2013.805213
    日期:2013.7.1
    A new Schiff base N-(5-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H2BMH) and its dioxomolybdenum(VI) complex [MoO2(BMH)(EtOH)] have been synthesized and characterized by elemental analysis, IR spectra, and single crystal X-ray determination. The Schiff base crystallized in the orthorhombic space group P2(1)2(1)2(1) and the complex crystallized in the triclinic space group . The Schiff base coordinates to Mo through the phenolate O, imine N, and enolic O. The asymmetric unit of the complex contains two mononuclear dioxomolybdenum molecules. Each Mo is six-coordinate octahedral. The only significant difference between the complex and the ligand is the geometry involving donors. The coordination of the ligand to Mo is also reflected in the IR spectra. The complex shows high catalytic property and selectivity in epoxidation of cyclohexene with t-butylhydroperoxide as oxidant.
  • Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances
    作者:Grzegorz Kazek、Monika Głuch-Lutwin、Barbara Mordyl、Elżbieta Menaszek、Monika Kubacka、Anna Jurowska、Dariusz Cież、Bartosz Trzewik、Janusz Szklarzewicz、Monika A. Papież
    DOI:10.3390/ph17020229
    日期:——
    characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the submicromolar range, as well as the inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar to bis(maltolato)oxidovanadium(IV) (BMOV). The ONS complexes increased [14C]-deoxy-D-glucose
    本文描述了新型 ONS 型钒 (V) 与氨基酸硫代苯胺衍生物配合物的合成和特性。他们表现出在亚微摩尔范围内对人类蛋白酪氨酸磷酸酶(PTP1B、LAR、SHP1 和 SHP2)的抑制作用,以及对非酪氨酸磷酸酶(CDC25A 和 PPA2)的抑制作用,与​​双(麦芽糖)氧化钒(IV)类似。 BMOV)。 ONS 复合物增加了 [14C]-脱氧-D-葡萄糖向 C2C12 肌细胞的转运,其中之一 VC070 也增强了 3T3-L1 脂肪细胞中的这种转运。这些复合物抑制肝细胞 HepG2 中的糖异生,但在使用相同细胞的非酒精性脂肪肝疾病模型中,它们都没有减少脂质积累。与所测试的以5-溴水杨醛和取代苯甲酰肼为席夫碱配体成分的ONO型钒配合物相比,ONS配合物对蛋白酪氨酸磷酸酶具有更强的抑制作用,但ONO配合物在细胞模型中总体上表现出更大的活性。此外,两组的大多数活性复合物均表现出比 VOSO4 和 BMOV
查看更多

同类化合物

(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐