methyl N-methylbenzimidate | 1775-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl N-methylbenzimidate
• 英文别名: N-methyl-benzimidic acid methyl ester；N-Methyl-benzimidsaeure-methylester；N-Methyl-benziminomethylaether；N-Methyl-benzimidsaeure-methylester；N-Methyl-benzimidomethylester；Methyl-N-methylbenzimidat；Benzenecarboximidic acid, N-methyl-, methyl ester；methyl N-methylbenzenecarboximidate
• CAS: 1775-61-7
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: ODCHIEXXFGKZNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl N-methylbenzimidate 生成 N,N-二甲基苯甲酰胺
  参考文献：
  名称：

  保留有顶端开窗的上乳切牙的有趣表现

  摘要：

  A case is described where intrusion of a primary incisor resulting in apical fenestration may have occurred secondary to occlusal forces. The effects on the permanent dentition and possible aetiological factors are discussed.

  DOI：

  10.1038/sj.bdj.4800483a
• 作为产物：
  描述：

  1-azido-1-phenylethyl methyl ether 330.0 ℃ 、13.33 Pa 条件下， 生成 methyl N-methylbenzimidate 、 Methyl-N-phenylacetimidat
  参考文献：
  名称：

  Synthetic methods. 25. Titanium tetrachloride-catalyzed addition of hydrazoic acid to aldehydes and ketones. Thermolysis and photolysis of .alpha.-azido ethers

  摘要：

  DOI：

  10.1021/jo00236a006

文献信息

• Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore
  作者：Masahiro Ikejiri、Kousuke Matsumoto、Hiraku Hasegawa、Daisuke Yamaguchi、Moe Tsuchino、Yoshiko Chihara、Takao Yamaguchi、Kazuto Mori、Takeshi Imanishi、Satoshi Obika、Kazuyuki Miyashita

  DOI：10.1016/j.tet.2015.05.073

  日期：2015.7

  New green fluorescent protein (GFP) chromophore analogues, namely 4-(diarylmethylene)imidazolinones (DAINs), were readily synthesized under weakly acidic conditions using a novel condensation reaction between methyl imidate (or thioimidate) and ethyl N-(diarylmethylene)glycinate. DAINs showed notable fluorescence properties. Although they were nearly non-fluorescent in the solution, visible emissions

  新的绿色荧光蛋白（GFP）生色团类似物，即4-（二芳基亚甲基）咪唑啉酮（DAIN），可以在弱酸性条件下使用亚氨酸甲酯（或硫代亚氨酸酯）和N-（二芳基亚甲基）甘氨酸乙酯之间的新型缩合反应轻松合成。DAINs显示出显着的荧光特性。尽管它们在溶液中几乎是无荧光的，但在大多数冷冻溶液状态和结晶粉末状态下都检测到可见光发射。因此，控制分子运动显着影响了DAIN的排放。DAIN 5a的荧光性质与相应的GFP生色团类似物8的荧光性质比较表明，5a 具有优异的固态荧光特性。
• Ag ^I ‐Catalyzed Reaction of Enol Diazoacetates and Imino Ethers: Synthesis of Highly Functionalized Pyrroles
  作者：Kuiyong Dong、Ahmad Humeidi、Wendell Griffith、Hadi Arman、Xinfang Xu、Michael P. Doyle

  DOI：10.1002/anie.202101641

  日期：2021.6.7

  AgI-catalyzed efficient method for the coupling of imino ethers and enol diazoacetates through a [3+2]-cycloaddition/C−O bond cleavage/[1,5]-proton transfer cascade process is reported. The general class of imino ethers that includes oxazolines, benzoxazoles and benzimidates are applicable substrates for these reactions that provide direct access to fully substituted pyrroles with uniformly high chemo- and

  报道了一种前所未有的 Ag I催化有效方法，用于通过 [3+2]-环加成/C-O 键裂解/[1,5]-质子转移级联过程偶联亚氨基醚和烯醇重氮乙酸酯。包括恶唑啉、苯并恶唑和苯甲亚胺酯在内的一般亚氨基醚类是这些反应的适用底物，可直接获得具有均匀高化学和区域选择性的完全取代的吡咯。吡咯 2-、5- 和 N-位取代的高度可变性表征了这种方法，该方法也提供了通过对所得 N-官能吡咯的轻松修饰来进一步实现吡咯多样化的切入点。
• Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position
  作者：Masahiro Ikejiri、Aki Yoshimizu、Fumika Shiota、Ai Nagayama、Aki Fujisaka、Yuichi Kuboki、Kazuyuki Miyashita

  DOI：10.1248/cpb.c24-00143

  日期：2024.5.31

  We have developed a series of 2-monoaryl-5-diarylmethylene analogs of the green fluorescent protein chromophore to study their viscosity-induced emission (VIE) properties. The analogs were synthesized by a condensation with methyl imidate and N-(diarylmethylene)glycinate. Among the analogs, the N-methylpyrrol-2-yl-substituted analog 1h induced the most remarkable VIE behavior in triglyceride and lipid

  我们开发了一系列绿色荧光蛋白发色团的 2-单芳基-5-二芳基亚甲基类似物，以研究它们的粘度诱导发射 (VIE) 特性。通过与亚氨酸甲酯和N- (二芳基亚甲基)甘氨酸酯缩合合成类似物。在这些类似物中， N-甲基吡咯-2-基取代的类似物1h在甘油三酯和脂质双层中诱导了最显着的 VIE 行为，这可能是由于吡咯环的高 π 电子丰富特性。咪唑啉酮类似物中的吡咯取代基有望成为引入 VIE 行为的通用模板。  全尺寸图像
• Nitrilium salts. New method for the synthesis of secondary amines
  作者：Richard F. Borch

  DOI：10.1021/jo01255a031

  日期：1969.3
• Lander, Journal of the Chemical Society, 1903, vol. 83, p. 327
  作者：Lander

  DOI：——

  日期：——