1,5-Dimethyl-3-(propylsulfanyl)-1H-pyrazole | 62652-35-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,5-Dimethyl-3-(propylsulfanyl)-1H-pyrazole
• 英文别名: 1,5-dimethyl-3-propylsulfanylpyrazole
• CAS: 62652-35-1
• 化学式: C₈H₁₄N₂S
• 分子量: 170.28
• InChiKey: BDWKWQCGCUDIGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Protein Kinase Conjugates and Inhibitors
  申请人：Celgene Avilomics Research, Inc.

  公开号：US20170174691A1

  公开（公告）日：2017-06-22

  The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.

  该发明涉及含有蛋白激酶的蛋白共轭物，该蛋白激酶在ATP结合位点含有半胱氨酸残基，并且与该半胱氨酸残基共价且不可逆地结合的抑制剂，从而不可逆地抑制了蛋白激酶的活性。该发明还涉及不可逆地抑制蛋白激酶的化合物。
• MK2 INHIBITORS AND USES THEREOF
  申请人：CELGENE AVILOMICS RESEARCH, INC.

  公开号：US20150376208A1

  公开（公告）日：2015-12-31

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供化合物，其组成物和使用方法。
• HETEROARYL COMPOUNDS AND USES THEREOF
  申请人：Celgene CAR LLC

  公开号：US20170267685A1

  公开（公告）日：2017-09-21

  The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention further provides for pharmaceutically acceptable compositions comprising therapeutically effective amounts of one or more of the protein kinase inhibitor compounds and methods of using said compositions in the treatment of cancers and carcinomas.
• US9796700B2
  申请人：——

  公开号：US9796700B2

  公开（公告）日：2017-10-24