N-[3-[1-[4-(2-hydroxyethyl)piperazinyl]propyl]]phthalimide | 6820-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-[3-[1-[4-(2-hydroxyethyl)piperazinyl]propyl]]phthalimide
• 英文别名: 1-<4-(2-Hydroxyethyl)-piperazino>-3-phthalimido-propan；N-{3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propyl}-phthalimide；N-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phthalimide；2-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]isoindole-1,3-dione
• CAS: 6820-97-9
• 化学式: C₁₇H₂₃N₃O₃
• 分子量: 317.388
• InChiKey: VFFAELIVUGJEFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[3-[1-[4-(2-hydroxyethyl)piperazinyl]propyl]]phthalimide 在 一水合肼 作用下， 以 二氯甲烷 、 戊醇 、 异丙醇 为溶剂， 反应 34.0h， 生成
  参考文献：
  名称：

  [EN] PYRIMIDINE COMPOUNDS AND USE THEREOF
  [FR] COMPOSÉS DE PYRIMIDINE ET LEUR UTILISATION

  摘要：

  Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy- induced peripheral neuropathy.

  公开号：

  WO2023014611A1
• 作为产物：
  描述：

  N-羟乙基哌嗪 、 N-(3-溴丙基)苯二胺 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以55 %的产率得到N-[3-[1-[4-(2-hydroxyethyl)piperazinyl]propyl]]phthalimide
  参考文献：
  名称：

  [EN] PYRIMIDINE COMPOUNDS AND USE THEREOF
  [FR] COMPOSÉS DE PYRIMIDINE ET LEUR UTILISATION

  摘要：

  Pyrimidine compounds of formula (I) shown herein. Also disclosed are pharmaceutical compositions containing one of the pyrimidine compounds and methods of using the pyrimidine compounds to treat or prevent chemotherapy- induced peripheral neuropathy.

  公开号：

  WO2023014611A1

文献信息

• Cephem compounds
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04443443A1

  公开（公告）日：1984-04-17

  This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; R.sup.2 is carboxy or a protected carboxy group; A is lower alkylene which may have an oxo group; R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; and R.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

  本发明涉及一种高抗微生物活性的新型头孢菌素化合物，其化学式为：##STR1##其中，R^1是氨基或保护氨基基团；R^2是羧基或保护羧基基团；A是较低的烷基，可能具有氧代基；R^3是羧基、保护羧基基团、较低的烷基、较低的烯基、羟基（较低的）烷基、苯基（较低的）烷基、苯基、甲苯基、二甲苯基、叔丁基或萘基；R^4是氢或较低的烷氧基，并且其药物学上可接受的盐。
• Cephem compounds and processes for preparation thereof
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04563524A1

  公开（公告）日：1986-01-07

  The invention relates to novel intermediates for preparing novel cephem compounds of high antimicrobial activity, the intermediates being of the formula: ##STR1## wherein A is lower alkylene which may have an oxo group; R.sup.3 is carboxy, protected carboxy, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, phenyl(lower)alkyl or aryl; and R.sup.7a is hydrogen or a mercapto-protective group, or a salt thereof.

  本发明涉及一种用于制备具有高抗微生物活性的新头孢菌素化合物的新中间体，该中间体的化学式为：##STR1## 其中，A是可以具有氧代基的低烷基；R.sup.3是羧基，保护羧基，低烷基，低烯基，羟基（低）烷基，苯基（低）烷基或芳基；R.sup.7a是氢或巯基保护基，或其盐。
• Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0029998A2

  公开（公告）日：1981-06-10

  A new cephem compound of the formula: wherein R' is amino or a substituted amino group; R2 is carboxy or a protected carboxy group; R is a group of the formula: -A1-R3a [in which A, is hydroxy(lower)alkylene, amino-(lower)alkylene, protected amino-(lower)alkylene, lower alkenylene or hydroxyimino(lower)alkylene wherein the hyrogen atom of the hydroxyimino group may be replaced with a lower aliphatic hydrocarbon group; and R3a is carboxy or a protected carboxy group] or a group of the formula:

  一种新的 Cephem 化合物，其化学式为 其中 R' 是氨基或取代的氨基； R2 是羧基或受保护的羧基； R 是式中的基团：-A1-R3a [其中 A 是羟基（低级）亚烷基、氨基（低级）亚烷基、受保护氨基（低级）亚烷基、低级烯基或羟基亚氨基（低级）亚烷基，其中羟基亚氨基基团的偶氮原子可被低级脂肪族烃基团取代；和 R3a 是羧基或受保护的羧基] 或 式中的一个基团：
• 5-Thio-tetrazol compounds and their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0095029A1

  公开（公告）日：1983-11-30

  Starting compounds of the formula wherein R is a group of the formula: --R3a [in which is hydroxy (C1-C6) alkylene, amino (C1-C6) alkylene, protected amino (C1-C6) alkylene, (C2-C6)alkenylene, (C,-C6) alkylene having an oxo group; or hydroxyimino (C1-C6) alkylene wherein the hydrogen atom of the hydroxyimino group may be replaced with a (C1-C6) aliphatic hydrocarbon group; and R38 is carboxy or an esterified carboxy group] or a group of the formula: [in which A2 is (C1-C6) alkylene which may have an oxo group; and R3b is carboxy, esterified carboxy, an aliphatic or aromatic group] and R10 is hydrogen or a mercapto-protective group, and a salt thereof and processes for their preparation. The compounds are useful for the preparation of cephem compounds.

  式中的起始化合物 其中 R 是式中的基团：--R3a [其中为羟基（C1-C6）亚烷基、氨基（C1-C6）亚烷基、受保护氨基（C1-C6）亚烷基、(C2-C6)烯基、具有氧代基团的（C,-C6）亚烷基； 或羟基亚氨基 (C1-C6) 亚烷基，其中羟基亚氨基基团的氢原子可被 (C1-C6) 脂肪族烃基团取代；以及 R38 是羧基或酯化羧基]或 式中的基团： [其中 A2 是（C1-C6）亚烷基，可带有一个氧代基团；以及 R3b 是羧基、酯化羧基、脂肪族或芳香族基团]和 R10 是氢或巯基保护基团，以及它们的盐 及其制备工艺。这些化合物可用于制备 cephem 化合物。
• Triterpene amine derivatives
  申请人：DFH THERAPEUTICS

  公开号：US11236122B2

  公开（公告）日：2022-02-01

  The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

  本发明涉及新型具有药用活性的三萜胺衍生物、含有三萜胺衍生物的药物组合物、其作为药物的用途，以及使用这些化合物制造特定药物。本发明还涉及一种涉及三萜胺化合物给药的治疗方法。具体来说，这些化合物是白桦脂酸的衍生物，在 C-3、C-28 和 C-19 位上有一个或多个取代位，如本文进一步描述的那样。这些新型化合物可用作抗逆转录病毒药物。特别是，这些新型化合物可用于治疗人类免疫缺陷病毒-1（HIV-1）。