O-iso-propyl methylphosphonate | 26458-69-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: O-iso-propyl methylphosphonate
• 英文别名: Methyl(propan-2-yloxy)phosphinate
• CAS: 26458-69-5
• 化学式: C₄H₁₀O₃P
• 分子量: 137.095
• InChiKey: GHZKGHQGPXBWSN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  沙林 在 1-hydroxy-1,2-benziodoxolin-3-one (6a) 水 作用下， 生成 O-iso-propyl methylphosphonate
  参考文献：
  名称：

  邻碘苯甲酸及其衍生物水解有毒有机磷化合物

  摘要：

  水解酯三甲基-1,2,2 丙基和异丙基甲基磷酰氟（soman 和 sarin 相关），du N,N-二甲基磷酰胺氰化物 d'ethyle (tabum) et du (diethyl nitro-4 phenyl) 磷酸 dans dessolutions aqueuses micelliaires de chlorure de (palmityl trimethyl) 铵, en d'acide iodosyl-«2»benzoique

  DOI：

  10.1021/ja00202a029

文献信息

• A Study of the Kinetics of La³⁺-Promoted Methanolysis of<i>S-</i>Aryl Methylphosphonothioates: Possible Methodology for Decontamination of EA 2192, the Toxic Byproduct of VX Hydrolysis
  作者：Basab B. Dhar、David R. Edwards、R. Stan Brown

  DOI：10.1021/ic200007v

  日期：2011.4.4

  The kinetics of the La3+-catalyzed methanolysis of a series of S-aryl methylphosphonothioates (4a e, phenyl substituents = 3,5-dichloro, 4-chloro, 4-fluoro, 4-H, 4-methoxy) were studied at 25 degrees C with (s)(s)pH control. The reaction involves saturation binding of the anionic substrates to dimeric La3+/methoxide catalysts formulated as La-2(3+)(-OCH3)(x) where x = 2-5 depending on the solution (s)(s)pH. Cleavage of the La3+-bound methylphosphonothioates is fast, ranging from 5 x 10(-3) s(-1) to 5.5 x 10(-5) s(-1) or substrates 4a-e at a:pH of 8.4 and 1.6 x 10(-1) s(-1) to 4 x 10(-3) s(-1) at a(s)(s)pH of 11.7. The rate accelerations for the methanolysis of substrates 4a e, relative to their background methoxide-promoted reactions, average 7 x 10(10) and 1.5 x 10(9), respectively, at (s)(s)pH's of 8.4 and 11.7. The catalytic system is predicted to cleave FA 2192 (S-2(N,N-di-iso-propylaminoethyl) methylphosphonothioate), a toxic byproduct of the hydrolysis of VX, with a t(1/2) between 4 and 8 min at a :pH of 8.4, and 27 min at a (s)(s)pH of 11.7.
• Pienaar, Andre; Modro, Tomasz A., Canadian Journal of Chemistry, 1995, vol. 73, # 6, p. 873 - 877
  作者：Pienaar, Andre、Modro, Tomasz A.

  DOI：——

  日期：——
• Hydrolysis of toxic organophosphorus compounds by o-iodosobenzoic acid and its derivatives
  作者：Philip S. Hammond、Jeffry S. Forster、Claire N. Lieske、H. Dupont Durst

  DOI：10.1021/ja00202a029

  日期：1989.9

  Hydrolyse des esters trimethyl-1,2,2 propyle et isopropyle de l'acide methyl phosphonofluoridique (soman et sarin respectivement), du N,N-dimethyl phosphoramidocyanidate d'ethyle (tabum) et du (diethyl nitro-4 phenyl) phosphate dans des solutions aqueuses micellaires de chlorure de (palmityl trimethyl) ammonium, en presence d'acide iodosyl-«2» benzoique

  水解酯三甲基-1,2,2 丙基和异丙基甲基磷酰氟（soman 和 sarin 相关），du N,N-二甲基磷酰胺氰化物 d'ethyle (tabum) et du (diethyl nitro-4 phenyl) 磷酸 dans dessolutions aqueuses micelliaires de chlorure de (palmityl trimethyl) 铵, en d'acide iodosyl-«2»benzoique