4'-Amino-3'-fluoro[1,1'-biphenyl]-4-carbaldehyde | 893738-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-Amino-3'-fluoro[1,1'-biphenyl]-4-carbaldehyde
• 英文别名: 4-(4-amino-3-fluorophenyl)benzaldehyde
• CAS: 893738-01-7
• 化学式: C₁₃H₁₀FNO
• 分子量: 215.22
• InChiKey: KOLQNUKGYAYGBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE BENZOIMIDAZOLE
  申请人：DAE WOONG PHARMA

  公开号：WO2012044043A2

  公开（公告）日：2012-04-05

  This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.