Dextroamphetamine phosphate | 7528-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dextroamphetamine phosphate
• 英文别名: (2S)-1-phenylpropan-2-amine;phosphoric acid
• CAS: 7528-00-9
• 化学式: C9H16NO4P
• 分子量: 233.2
• InChiKey: ZHVLGOLHHYJSBZ-QRPNPIFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.65
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Ascending-dose dosage form
  申请人：ALZA CORPORATION

  公开号：EP1782798A2

  公开（公告）日：2007-05-09

  A dosage form and a method are disclosed for delivering to a human patient a drug in an ascending amount over time. In particular, the invention provides a dosage form having a length greater than its width, the dosage form comprising: (a) a first layer comprising 10 ng to 700 mg of a drug selected from methylphenidate or a pharmaceutically acceptable salt thereof; (b) a second layer comprising 80% to 95% of a hydrophilic-expandable polymer; (c) a wall comprising a semipermeable composition that surrounds the first and second layer; (d) an exit in the wall communicating with the first layer for delivering the drug; and wherein the dosage form when in operation administers the drug in an ascending rate over time.

  本发明公开了一种剂型和一种方法，用于向人类患者递送随时间递增的药物。特别是，本发明提供了一种长度大于宽度的剂型，该剂型包括 (a) 第一层，包含 10 毫微克至 700 毫克选自哌醋甲酯或其药学上可接受的盐的药物； (b) 第二层，包括 80%至 95%的亲水性可膨胀聚合物； (c) 包含半透性成分的壁，环绕第一层和第二层； (d) 壁中与第一层相通的出口，用于递送药物；以及其中的剂型在使用时以随时间递增的速率递送药物。
• Pharmaceutical dosage form for pulsatile delivery of methylphenidate
  申请人：——

  公开号：US20020058061A1

  公开（公告）日：2002-05-16

  Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart “pulses.” The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

  新型药物剂型可脉冲式释放哌醋甲酯，即以间隔的 "脉冲 "方式释放封装药物。这些剂型由第一、第二和可选的第三剂量单位组成，每个剂量单位具有不同的药物释放曲线。这些剂型可包括容纳压缩片剂或含药微珠或微粒的胶囊，也可包括第一、第二和第三剂量单位各自代表其整体和离散部分的单一片剂。此外，还提供了使用药物剂型的治疗方法。
• Chronotherapeutic dosage forms and methods of treatment using chronotherapy
  申请人：——

  公开号：US20030082230A1

  公开（公告）日：2003-05-01

  A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.

  一种慢性治疗药物制剂，包括含有活性剂（如药物）的核心和涂在核心表面的由天然或合成胶组成的缓释压缩涂层。
• Sustained release matrix systems for highly soluble drugs
  申请人：Penwest Pharmaceuticals Co.

  公开号：US20040170684A1

  公开（公告）日：2004-09-02

  Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a sustained release matrix comprising a gelling agent, said gelling agent comprising a heteropolysaccharide gum and a homopolysaccharide gum capable of cross-linking said heteropolysaccharide gum when exposed to an environmental fluid, said dosage form providing a sustained release of said medicament after oral administration to human patients.

  本发明公开了一种缓释口服固体制剂，该制剂包含治疗有效量的药物，其溶解度大于约 10 克/升；pH 值调节剂；以及缓释基质，该基质包含胶凝剂，所述胶凝剂包含杂多糖胶和同源多糖胶，当暴露于环境流体时，所述杂多糖胶能够交联，所述制剂可在人类患者口服后持续释放所述药物。
• Chronotherapeutic dosage forms
  申请人：Baichwal R. Anand

  公开号：US20050118267A1

  公开（公告）日：2005-06-02

  A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a surfactant and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.

  一种慢性治疗药物制剂，包括含有活性剂（如药物）和表面活性剂的核心，以及涂在核心表面的由天然或合成胶组成的缓释压缩涂层。