Cephamycin A | 34279-78-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: Cephamycin A
• 英文别名: (6R,7S)-7-[[(5R)-5-amino-5-carboxypentanoyl]amino]-7-methoxy-3-[[(Z)-2-methoxy-3-(4-sulfooxyphenyl)prop-2-enoyl]oxymethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS: 34279-78-2
• 化学式: C₂₅H₂₉N₃O₁₄S₂
• 分子量: 659.6
• InChiKey: AGMXVTRKEHGDRH-MYWSHXOVSA-N

物化性质

• 密度：
  1.65±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  292
• 氢给体数：
  5
• 氢受体数：
  16

文献信息

• Prodrugs
  申请人：MEDIVIR AB

  公开号：US20030186924A1

  公开（公告）日：2003-10-02

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig 1

  一种治疗HBV和HIV感染的方法，包括给予化合物或公式Ig1的盐。
• Antiviral methods employing double esters of 2', 3'-dideoxy-3'-fluoroguanosine
  申请人：Zhou Xiao-Xiong

  公开号：US20060122383A1

  公开（公告）日：2006-06-08

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig

  一种治疗HBV和HIV感染的方法，包括给予化合物或公式Ig的盐。
• Carboxylic acid esters of pharmaceutical compounds
  申请人：Ascher Gerd

  公开号：US20060122164A1

  公开（公告）日：2006-06-08

  A pharmaceutically active compound having a carboxylic acid group —COOH as a part of its chemical structure which —COOH group is in the form of a carboxylic acid ester.

  一种具有羧酸基—COOH作为其化学结构的药物活性化合物，其中—COOH基团以羧酸酯的形式存在。
• Delivery of drug esters through an inhalation route
  申请人：Alexza Molecular Delivery Corporation

  公开号：US20040156790A1

  公开（公告）日：2004-08-12

  The present invention relates to the delivery of drug esters through an inhalation route. Specifically, it relates to aerosols containing drug esters that are used in inhalation therapy. In a method aspect of the present invention, a drug ester is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises a drug ester, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug ester degradation product. In a kit aspect of the present invention, a kit for delivering a drug ester through an inhalation route is provided which comprises: a) a thin coating of a drug ester composition and b) a device for dispensing said thin coating as a condensation aerosol.

  本发明涉及通过吸入途径输送药物酯类的方法。具体而言，涉及用于吸入治疗的含有药物酯类的气溶胶。在本发明的方法方面，通过吸入途径向患者输送药物酯类。该方法包括：a）加热组合物，其中该组合物包括药物酯类，以形成蒸汽；并且，b）允许蒸汽冷却，从而形成凝结气溶胶，其中包含少于5％的药物酯类降解产物。在本发明的工具方面，提供了一种通过吸入途径输送药物酯类的工具套件，该套件包括：a）药物酯类组合物的薄涂层和b）用于将该薄涂层作为凝结气溶胶分配的设备。
• ANTIVIRAL METHODS EMPLOYING DOUBLE ESTERS OF 2', 3'-DIDEOXY-3'-FLUOROGUANOSINE
  申请人：Zhou Xiao-Xiong

  公开号：US20060058259A1

  公开（公告）日：2006-03-16

  A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig

  一种治疗乙型肝炎和人类免疫缺陷病毒感染的方法，包括给予公式Ig的化合物或盐。