9-(2-hydroxyethoxymethyl)guanine methyl phosphate | 94889-86-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2-hydroxyethoxymethyl)guanine methyl phosphate
• 英文别名: 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl methyl hydrogen phosphate
• CAS: 94889-86-8
• 化学式: C₉H₁₄N₅O₆P
• 分子量: 319.214
• InChiKey: JQDXMLGVKJHXKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  阿昔洛韦 在 磷酸三乙酯 、 水 、 三氯氧磷 作用下， 反应 6.5h， 生成 9-(2-hydroxyethoxymethyl)guanine methyl phosphate 、 9-[[2-氯乙氧基]甲基]鸟嘌呤
  参考文献：
  名称：

  Phosphoramidate derivatives of acyclovir, inhibitors of herpes virus replication

  摘要：

  A series of new acyclovir phosphoramidates-potential antiviral agents against resistant strains of herpes virus-was synthesized. Of several approaches used for their synthesis, the treatment of the intermediate phosphorochloridate with various amines proved to be optimal. Two of the synthesized compounds were moderately active against HSV-1.

  DOI：

  10.1134/s1068162011050190

文献信息

• COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS
  申请人：Hill Gordon Craig

  公开号：US20090286732A1

  公开（公告）日：2009-11-19

  The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
• US8232251B2
  申请人：——

  公开号：US8232251B2

  公开（公告）日：2012-07-31
• Phosphoramidate derivatives of acyclovir, inhibitors of herpes virus replication
  作者：N. F. Zakirova、A. V. Shipitsyn、M. V. Jasko、S. N. Kochetkov

  DOI：10.1134/s1068162011050190

  日期：2011.9

  A series of new acyclovir phosphoramidates-potential antiviral agents against resistant strains of herpes virus-was synthesized. Of several approaches used for their synthesis, the treatment of the intermediate phosphorochloridate with various amines proved to be optimal. Two of the synthesized compounds were moderately active against HSV-1.