tetraethyldiamidophenylphosphite | 14684-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tetraethyldiamidophenylphosphite
• 英文别名: Phenyl tetraethyldi-amidophosphite；N-[diethylamino(phenoxy)phosphanyl]-N-ethylethanamine
• CAS: 14684-28-7
• 化学式: C₁₄H₂₅N₂OP
• 分子量: 268.339
• InChiKey: ADCIIHGOUXUHRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tetraethyldiamidophenylphosphite 以 1,4-二氧六环 、 苯 为溶剂， 反应 2388.0h， 生成 六乙基亚磷酸胺
  参考文献：
  名称：

  Dismutation of Diamidoarylphosphites

  摘要：

  Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.

  DOI：

  10.1080/714040960
• 作为产物：
  描述：

  六乙基亚磷酸胺 以 1,4-二氧六环 为溶剂， 反应 552.0h， 生成 tetraethyldiamidophenylphosphite
  参考文献：
  名称：

  Dismutation of Diamidoarylphosphites

  摘要：

  Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.

  DOI：

  10.1080/714040960

文献信息

• Cyclic bis-amidophosphites based on 1,6-dihydroxynaphthalene
  作者：P. V. Slitikov、E. N. Rasadkina、L. K. Vasyanina、E. E. Nifant’ev

  DOI：10.1007/s11172-013-0293-9

  日期：2013.9

  Phosphorylation of 1,6-dihydroxynaphthalene with various triamidophosphites gives 2: 2 cyclic adducts with the 1,6′,1′,6-bonding of the naphthalenediyl moieties through the amidophosphite bridges.

  将 1,6-二羟基萘与各种三脒亚磷酸酯进行磷酸化，可得到 2:2 环状加合物，萘二基通过脒基亚磷酸酯桥实现 1,6′,1′,6-键连接。
• Selective phosphorylation of dihydroquercetin with trivalent phosphorus reagents
  作者：E. E. Nifant'ev、T. S. Kukhareva、Z. M. Dzgoeva、L. K. Vasyanina、M. P. Koroteev、G. Z. Kaziev

  DOI：10.1002/hc.10115

  日期：——

  Characteristic features of phosphorylation of dihydroquercetin with trivalent phosphorus reagents were studied. Preparative methods for regioselective phosphorylation were found. The most important chemical properties of dihydroquercetin phosphites and cyclophosphites were studied. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:399–403, 2003; Published online in Wiley InterScience (www.interscience

  研究了三价磷试剂磷酸化二氢槲皮素的特性。发现了区域选择性磷酸化的制备方法。研究了二氢槲皮素亚磷酸酯和环亚磷酸酯最重要的化学性质。© 2003 Wiley Periodicals, Inc. 杂原子化学 14:399–403, 2003; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.10115
• Regiodirected phosphorylation of 2,2′,7,7′-tetrahydroxydinaphthylmethane
  作者：Vera I. Maslennikova、Tatyana Yu. Sotova、Larisa K. Vasyanina、Konstantin A. Lyssenko、Mikhail Yu. Antipin、Sergei O. Adamson、Andrei I. Dementyev、Wolf D. Habicher、Eduard E. Nifantyev

  DOI：10.1016/j.tet.2007.02.095

  日期：2007.5

  studied and the influence of molecule pre-organization on the regioselectivity of functionalization was investigated. The reactions of 2,2′,7,7′-tetrahydroxydinaphthylmethane with phosphorous amides containing 1–3 amide bonds gave oligophosphorylated derivatives differing in the number and the nature of phosphorus fragments and in the size of phosphorus rings: tetraphosphorus macrocycles containing one

  研究了2,2'，7,7'-四羟基二萘甲基甲烷的磷酸化，并研究了分子预组织对官能化区域选择性的影响。2,2'，7,7'-四羟基二萘甲甲烷与含有1-3个酰胺键的磷酰胺的反应生成的寡磷酸化衍生物的磷片段的数量和性质以及磷环的大小不同：四磷大环含有一个24-元和两个八元磷环，包含磷环和两个无环磷片段的三磷化合物以及分子中具有四个磷基的四磷酸化衍生物。证明了通过使用PN键数量和活性不同的试剂来控制磷酸化区域选择性的可能性。
• O-aryl phosphoramidites: synthesis, reactivity and evaluation of their use for solid-phase synthesis of oligonucleotides
  作者：Ramon Eritja、Valeriy Smirnov、Marvin H. Caruthers

  DOI：10.1016/s0040-4020(01)81356-9

  日期：1990.1
• Dismutation of arylene phosphorodiamidites: Specific features and aspects of preparative use
  作者：E. N. Rasadkina、P. V. Slitikov、E. E. Nifant’ev

  DOI：10.1134/s1070363206020046

  日期：2006.2

  The dismutation ofarylene phosphorodiamidites derived from the simplest phenols and naphthols and of their dibasic analogs was studied. The main regular trends of this process and the limits of its synthetic applicability were determined.