(1R,5R)-4,7,7-trimethyl-6-thiabicyclo[3.2.1]oct-3-ene | 1208985-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: (1R,5R)-4,7,7-trimethyl-6-thiabicyclo[3.2.1]oct-3-ene
• 英文别名: (4R,6R)-6,8-epithio-p-menth-1-ene；(4R,6R)-6,8-Epithio-p-menth-1-en
• CAS: 1208985-44-7
• 化学式: C₁₀H₁₆S
• 分子量: 168.303
• InChiKey: ODZMYNHWVMNAFY-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1R,5R)-4,7,7-trimethyl-6-thiabicyclo[3.2.1]oct-3-ene 在 甲醇 、 palladium on activated charcoal 、 双氧水 、 溶剂黄146 作用下， 生成 (1R,2R,4R)-2,8-episulfonyl-p-menthane
  参考文献：
  名称：

  I. The Action of Sulfur on Terpenes. The Limonene Sulfides

  摘要：

  DOI：

  10.1021/ja01522a069
• 作为产物：
  描述：

  甜橙提取物 在 sulfur 作用下， 生成 (1R,5R)-4,7,7-trimethyl-6-thiabicyclo[3.2.1]oct-3-ene
  参考文献：
  名称：

  I. The Action of Sulfur on Terpenes. The Limonene Sulfides

  摘要：

  DOI：

  10.1021/ja01522a069

文献信息

• Practical and Highly Selective Sulfur Ylide-Mediated Asymmetric Epoxidations and Aziridinations Using a Cheap and Readily Available Chiral Sulfide: Extensive Studies To Map Out Scope, Limitations, and Rationalization of Diastereo- and Enantioselectivities
  作者：Ona Illa、Mariam Namutebi、Chandreyee Saha、Mehrnoosh Ostovar、C. Chun Chen、Mairi F. Haddow、Sophie Nocquet-Thibault、Matteo Lusi、Eoghan M. McGarrigle、Varinder K. Aggarwal

  DOI：10.1021/ja405073w

  日期：2013.8.14

  The chiral sulfide, isothiocineole, has been synthesized in one step from elemental sulfur, γ-terpinene, and limonene in 61% yield. A mechanism involving radical intermediates for this reaction is proposed based on experimental evidence. The application of isothiocineole to the asymmetric epoxidation of aldehydes and the aziridination of imines is described. Excellent enantioselectivities and diastereoselectivities

  手性硫化物异硫辛醇由元素硫、γ-萜品烯和柠檬烯一步合成，产率为 61%。基于实验证据提出了涉及该反应的自由基中间体的机制。描述了异硫辛醇在醛的不对称环氧化和亚胺的氮丙啶化中的应用。使用简单的实验方案已在广泛的芳香族、脂肪族和 α,β-不饱和醛中获得了出色的对映选择性和非对映选择性。在氮丙啶化反应中，对多种亚胺都具有优异的对映选择性和良好的非对映选择性。已经提出了机械模型来合理化观察到的高选择性，这应该使硫化物能够在合成中充满信心地使用。在环氧化中，甜菜碱形成的可逆程度决定了非对映选择性和对映选择性。在了解反应机理的基础上适当调整反应条件可以在大多数情况下获得高选择性。在氮丙啶化反应中，甜菜碱的形成与半稳定的叶立德是不可逆的，非对映选择性在甜菜碱形成步骤中确定，因此变化更大。
• PROCESS FOR PREPARING POLYSUCCINIMIDE DERIVATIVES-BASED MICROCAPSULES
  申请人：Firmenich SA

  公开号：US20210316266A1

  公开（公告）日：2021-10-14

  Described herein is a new process for the preparation of polysuccinimide derivatives-based core-shell microcapsules. Also described are microcapsules, as well as perfuming compositions and consumer products including these microcapsules, in particular perfumed consumer products in the form of home care or personal care products.

  本文介绍了一种新的制备基于聚丁二酸亚酰胺衍生物的核-壳微胶囊的过程。还介绍了微胶囊，以及包括这些微胶囊的香料组合物和消费品，特别是家居护理或个人护理产品的香料消费品。
• Density balanced high impact perfume microcapsules
  申请人：FIRMENICH SA

  公开号：US10918579B2

  公开（公告）日：2021-02-16

  Described herein are microcapsules having an oil-based core and a polymeric shell, where the oil-based core includes a perfume oil having high impact perfume raw materials and a density balancing material. Perfuming compositions and consumer products including said microcapsules, in particular isotropic or structured consumer products in the form of home care or personal care products, are also described herein.

  本文描述了具有油基核心和聚合物外壳的微胶囊，其中油基核心包括具有高影响香水原料的香水油和密度平衡材料。 本文还描述了包括所述微胶囊的香水组合物和消费品，特别是家庭护理或个人护理产品形式的各向同性或结构化消费品。
• HAIR COLORING COMPOSITION COMPRISING MICROCAPSULES
  申请人：FIRMENICH SA

  公开号：US20200368121A1

  公开（公告）日：2020-11-26

  The present disclosure relates to the field of hair coloring compositions. Described herein is an oxidative hair coloring composition including microcapsules made of a perfumed-oil based core and a polymeric shell. Also described herein are a method for coloring hair and a hair coloring kit.
• PROCESS FOR PREPARING MICROCAPSULES
  申请人：FIRMENICH SA

  公开号：US20210106964A1

  公开（公告）日：2021-04-15

  Described herein is a new process for the preparation of core-shell microcapsules. Also described herein are microcapsules. Also described herein are consumer products including said microcapsules, in particular perfumed consumer products or flavoured consumer products.