5-(2-呋喃基)- | 92233-50-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 中文名称: 5-(2-呋喃基)-
• 英文名称: 5-(Furan-2-yl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 92233-50-6
• 化学式: C₁₃H₁₄N₂O₆
• 分子量: 294.26
• InChiKey: IWTGFYBALHWJGB-UHFFFAOYSA-N

物化性质

• 密度：
  1.518±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIE
  申请人：SPEROVIE BIOSCIENCES INC

  公开号：WO2018013908A1

  公开（公告）日：2018-01-18

  This invention relates to compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof.

  这项发明涉及用于诱导模式识别受体（例如STING）表达的化合物和组合物，以及其使用方法。
• Fluorescent Nucleoside Analogs That Mimic Naturally Occurring Nucleosides
  申请人：Tor Yitzhak

  公开号：US20080261823A1

  公开（公告）日：2008-10-23

  The present invention provides fluorescent nucleoside analogs with conjugated membered heterocycles, including furan and thiophene. The fluorescent nucleoside analogs maintain structural similarity to naturally occurring nucleoside bases, mimicking shape, size, hybridization, and recognition properties. Incorporation of the fluorescent cyclic compounds confers specific photophysical characteristics including a bathochromic (red) shift of the absorption spectrum to minimize absorption overlap with naturally occurring nucleoside bases, and a shift to the long emission wavelength in the visible range. The invention also provides for various methods of synthesizing the fluorescent nucleoside analogs and incorporating the fluorescent analogs in DNA, RNA, or oligomer synthesis. Further, methods of detecting the fluorescent nucleoside analogs in an oligonucleotide or oligomer are provided. The subject compounds are useful as probes in the study of the structure and dynamics of nucleic acids and their complexes with proteins.
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
  申请人：Sperovie Biosciences, Inc.

  公开号：US20190292215A1

  公开（公告）日：2019-09-26

  Disclosed are compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof.