bis-(4-dimethylamino-phenyl)-carbodiimide | 738-65-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-(4-dimethylamino-phenyl)-carbodiimide
• 英文别名: Bis-(4-dimethylamino-phenyl)-carbodiimid；Bis(p-dimethylaminophenyl)carbodiimide
• CAS: 738-65-8
• 化学式: C₁₇H₂₀N₄
• 分子量: 280.373
• InChiKey: ABFDTYJJUSUWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis-(4-dimethylamino-phenyl)-carbodiimide 在 吡啶 、 乙醚 作用下， 生成 N,N'-bis-(4-dimethylamino-phenyl)-N-(-salicylidenamino-benzoyl)-urea
  参考文献：
  名称：

  Zetzsche; Voigt, Chemische Berichte, 1941, vol. 74, p. 183,186

  摘要：

  DOI：
• 作为产物：
  描述：

  4,4'-二(二甲基氨基)硫代对称二苯脲 在 magnesium sulfate 、 mercury(II) oxide 、 苯 作用下， 生成 bis-(4-dimethylamino-phenyl)-carbodiimide
  参考文献：
  名称：

  Das; Niyogy, Annals of biochemistry and experimental medicine, 1956, vol. 16, p. 5,7

  摘要：

  DOI：

文献信息

• BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20160340374A1

  公开（公告）日：2016-11-24

  An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound. The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R 1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R 2 to R 4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z + represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)

  本发明的目的是提供一种化合物，能够在与碱反应性化合物混合状态长时间存储的情况下，仍能获得具有高储存稳定性的组合物，而不与碱反应性化合物发生反应，同时还能通过光照（活性能量射线）或加热产生强碱（胍胺、双胍胺、磷氮烷或磷銨）；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。本发明涉及由通式（A）表示的化合物；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。（其中R1代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；烯基；2-呋喃基炔基；2-噻吩基炔基；或2,6-二硫基基；R2到R4各自独立地代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基；呋喃基；噻吩基；或N-烷基取代的吡咯基；Z+代表具有胍胺基团、双胍胺基团或磷氮烷基团的铵阳离子，或磷銨阳离子。）
• ACID-RESISTANT BASE AND/OR RADICAL GENERATOR, AND CURABLE RESIN COMPOSITION CONTAINING SAID BASE AND/OR RADICAL GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20190002403A1

  公开（公告）日：2019-01-03

  The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so on. In the formula, four pieces of R 1 each independently represents a hydrogen atom or a fluorine atom; four pieces of R 2 each independently represent a fluorine atom or a trifluoromethyl group; R 3 , R 6 , R 7 and R 10 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; R 4 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, or R 4 and R 5 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; and R 8 and R 9 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or an aryl group having 6 to 14 carbon atoms and optionally having a substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a dialkylamino group having 2 to 12 carbon atoms, a halogen atom, and a nitro group, or R 8 and R 9 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; provided that two or three of the eight groups R 3 to R 10 are each a hydrogen atom, and, in a case where two of the eight groups are each a hydrogen atom, then three to six of the remaining groups are each an alkyl group having 1 to 12 carbon atoms, and, in a case where three of the eight groups are each a hydrogen atom, then four or five of the remaining groups are each an alkyl group having 1 to 12 carbon atoms.

  本发明涉及一种由通式（A）表示的化合物，包括该化合物的生成碱基和/或基团产生剂等。在该式中，四个R1分别独立表示氢原子或氟原子；四个R2分别独立表示氟原子或三氟甲基基团；R3、R6、R7和R10分别独立表示氢原子或具有1至12个碳原子的烷基基团；R4和R5分别独立表示氢原子或具有1至12个碳原子的烷基基团，或者R4和R5相互连接表示具有2至4个碳原子的亚烷基基团；R8和R9分别独立表示氢原子、具有1至12个碳原子的烷基基团或具有6至14个碳原子且可选地具有选自包括具有1至6个碳原子的烷基基团、具有1至6个碳原子的烷氧基团、具有1至6个碳原子的烷硫基团、具有2至12个碳原子的二烷基氨基团、卤素原子和硝基基团的取代基的芳基团，或者R8和R9相互连接表示具有2至4个碳原子的亚烷基基团；前提是八个基团R3至R10中的两个或三个分别是氢原子，并且在其中两个基团分别是氢原子的情况下，其余基团中的三到六个分别是具有1至12个碳原子的烷基基团，而在其中三个基团分别是氢原子的情况下，其余基团中的四个或五个分别是具有1至12个碳原子的烷基基团。
• Dipolar 1,3-cycloaddition of arylnitriloxides on 1,2-dihydroisoquinolines in a two-phase medium
  作者：Said Kitane、Amina Taimi、Abdelmejid Bahloul、Abdelfatah Sebban、Mohamed Berrada、Jean-Pierre Joly

  DOI：10.1002/jhet.5570370639

  日期：2000.11

  The 1,3-dipolar cycloaddition of arylnitriloxides on 1,2-dihydroisoquinoline derivatives led to new 3-aryl, 3a-8,9,9a-tetrahydro[5,4-c]-isoxazoloisoquinoline adducts. The regioselectivity of the cycloaddition reactions is discussed on the basis of 1H and 13C NMR data.

  1,2-二氢异喹啉衍生物上芳基腈的1,3-偶极环加成反应生成新的3-芳基，3a-8,9,9a-四氢[5,4- c ]-异恶唑异喹啉加合物。基于1 H和13 C NMR数据讨论了环加成反应的区域选择性。
• Crystalline beta-lactam solvate
  申请人：ELI LILLY AND COMPANY

  公开号：EP0327364A1

  公开（公告）日：1989-08-09

  The crystalline 2.5 hydrate of 7β-[2′-(R)-2′-­(m-(methylsulfonamido)phenyl)-2′-aminoacetamido]-3-­chloro-3-(1-carbadethiacephem)-4-carboxylic acid is an antibiotic with superior pharmaceutical elegance. Pharmaceutical formulations of the crystalline 2.5 hydrate are also described.

  7β-[2′-(R)-2′-(m-(甲基磺酰氨基)苯基)-2′-氨基乙酰氨基]-3-氯-3-(1-卡巴德硫氨酰头孢)-4-羧酸的结晶2.5水合物是一种具有优越药学优雅度的抗生素。还描述了该结晶2.5水合物的制药配方。
• Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders
  申请人：Rafferty Michael

  公开号：US20090111813A1

  公开（公告）日：2009-04-30

  The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.

  现有实施例与以下公式1或公式2的化合物及其制药配方以及使用制药配方治疗各种中枢神经系统疾病有关。一些实施例包括使用各种即时化合物，这些化合物与哌加宾相比出人意料地展示出改善的药代动力学和治疗特征。