Thymidin

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Thymidin
• 英文别名: 1-[(4R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C₁₀H₁₄N₂O₅
• 分子量: 242.232
• InChiKey: IQFYYKKMVGJFEH-JECWYVHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Polymerizable Compound, Compound, and Method for Producing Boranophosphate Oligomer
  申请人：TOKYO UNIVERSITY OF SCIENCE FOUNDATION

  公开号：US20190270765A1

  公开（公告）日：2019-09-05

  Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, R 1 represents an electron-donating group; n represents an integer from 1 to 5; R 2 represents a hydrogen atom, a halogen atom, or —OR O , wherein R O represents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; R 3 represents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.

  提供一种由以下化学式A-1或化学式A-2表示的可聚合化合物：在化学式A-1或化学式A-2中，R1代表一个电子给予基团；n代表一个从1到5的整数；R2代表一个氢原子、卤素原子或—ORO，其中RO代表一个氢原子、烷基基团或一个羟基的保护基团；R3代表一个氢原子或一个羟基的保护基团；X代表由化学式B-1到化学式B-5中的任意一个表示的结构。
• IMAGING METHOD FOR ACUTE LYMPHOBLASTIC LEUKEMIA USING AN IMAGING AGENT AND METHOD OF PRODUCING AN IMAGING AGENT
  申请人：Satz Stanley

  公开号：US20190261858A1

  公开（公告）日：2019-08-29

  The present invention provides an in vivo imaging method that facilitates the diagnosis of Acute Lymphoblastic Leukemia (ALL) at an early stage. Early diagnosis is particularly advantageous as a tool to select more aggressive therapy, to estimate the success rate for visualizing ALL at the time of diagnosis.

  本发明提供了一种体内成像方法，有助于早期诊断急性淋巴细胞白血病（ALL）。早期诊断特别有利于选择更积极的治疗方案，以估计在诊断时可视化ALL的成功率。
• Nucleotide analogs for sequencing
  申请人：IBIS BIOSCIENCES, INC.

  公开号：US10428379B2

  公开（公告）日：2019-10-01

  Provided herein is technology relating to sequencing nucleic acids, but not exclusively, to compositions, methods, systems, and kits related to nucleotides comprising an electrochemically detectable moiety and one or more photolabile synthesis-inhibiting moieties.

  本文提供的是与核酸测序有关的技术，但不限于与核苷酸有关的组合物、方法、系统和试剂盒，这些核苷酸包含电化学可检测分子和一个或多个可光化的合成抑制分子。
• USE OF MICROFABRICATED DEVICES
  申请人：HAMMERSMITH IMANET LIMITED

  公开号：US20140316130A1

  公开（公告）日：2014-10-23

  This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).
• OLIGONUCLEOTIDE PRODUCTION METHOD
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20190169223A1

  公开（公告）日：2019-06-06

  The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. The oligonucleotide production method includes a step of subjecting a nucleoside or oligonucleotide having a pseudo solid phase-protecting group in at least one location selected from the group consisting of 2′-position, 3′-position, 5′-position and a nucleobase moiety and having a 5′-hydroxyl group or a 3′-hydroxyl group, to H-phosphonation to convert the 5′-hydroxyl group or the 3′-hydroxyl group into an H-phosphonated form.