N²-acetyl-O⁶-methylguanine | 1061382-73-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N²-acetyl-O⁶-methylguanine
• 英文别名: N-(6-methoxy-7H-purin-2-yl)acetamide
• CAS: 1061382-73-7
• 化学式: C₈H₉N₅O₂
• 分子量: 207.192
• InChiKey: GKFISIKBQRNOCB-UHFFFAOYSA-N

物化性质

• 密度：
  1.494±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N²-acetyl-O⁶-methylguanine 、 beta-胸苷 在 purine nucleoside phosphorylase 、 potassium phosphate buffer 作用下， 以95%的产率得到N-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methoxypurin-2-yl]acetamide
  参考文献：
  名称：

  An Enzymatic Transglycosylation of Purine Bases

  摘要：

  An enzymatic transglycosylation of purine heterocyclic bases employing readily available natural nucleosides or sugar-modified nucleosides as donors of the pentofuranose fragment and recombinant nucleoside phosphorylases as biocatalysts has been investigated. An efficient enzymatic method is suggested for the synthesis of purine nucleosides containing diverse substituents at the C6 and C2 carbon atoms. The glycosylation of N-6-benzoyladenine and N-2-acetylguanine and its O-6-derivatives is not accompanied by deacylation of bases.

  DOI：

  10.1080/15257770701506343

文献信息

• An Enzymatic Transglycosylation of Purine Bases
  作者：Jarkko Roivainen、Tatiana Elizarova、Seppo Lapinjoki、Igor A. Mikhailopulo、Roman S. Esipov、Anatoly I. Miroshnikov

  DOI：10.1080/15257770701506343

  日期：2007.11.26

  An enzymatic transglycosylation of purine heterocyclic bases employing readily available natural nucleosides or sugar-modified nucleosides as donors of the pentofuranose fragment and recombinant nucleoside phosphorylases as biocatalysts has been investigated. An efficient enzymatic method is suggested for the synthesis of purine nucleosides containing diverse substituents at the C6 and C2 carbon atoms. The glycosylation of N-6-benzoyladenine and N-2-acetylguanine and its O-6-derivatives is not accompanied by deacylation of bases.