1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione, caffeine; compound with sodium benzoate | 8000-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione, caffeine; compound with sodium benzoate
• 英文别名: 1,3,7-Trimethyl-3,7-dihydro-purin-2,6-dion, Kaffein; Verbindung mit Natriumbenzoat；CAFFEINE and SODIUM BENZOATE；sodium;1,3,7-trimethylpurine-2,6-dione;benzoate
• CAS: 8000-95-1；82783-24-2
• 化学式: 2C₇H₅O₂*C₈H₁₀N₄O₂*2Na
• 分子量: 482.404
• InChiKey: JWBPVFVNISJVEM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.98
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  98.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  咖啡因 、 sodium benzoate 以 水 为溶剂， 生成 1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione, caffeine; compound with sodium benzoate
  参考文献：
  名称：

  FOOD PRODUCTS HAVING CAFFEINE INCORPORATED THEREIN

  摘要：

  本发明提供了添加剂的食品产品，可用于提供所需的效果，例如刺激效果。在一种实施例中，本发明涉及具有咖啡因添加量的食品产品。在具体实施例中，食品产品是甜甜圈、百吉饼或早餐棒。

  公开号：

  US20080152763A1

文献信息

• A multi-layered chewing gum composition and a process for the production thereof
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0150934A2

  公开（公告）日：1985-08-07

  There is disclosed a chewing gum composition which comprises a first region, a second region and, optionally, one or more further regions, each region having a different composition, wherein each region is capable of releasing a flavour at a different rate, wherein the first region comprises from 14% to 18% by weight of a gum base and a flavouring agent, and wherein the second region comprises at least 22% by weight of a gum base and a flavouring agent, the percentages being based on the weight of the respective regions of the chewing gum composition. The chewing gums have enhanced flavour impact and quick and sustained flavour release characteristics.

  本发明公开了一种口香糖组合物，它包括一个第一区域、一个第二区域和可选的一个或多个其他区域，每个区域具有不同的成分，其中每个区域能够以不同的速度释放香味，其中第一区域包括按重量计14%至18%的胶基和香味剂，第二区域包括按重量计至少22%的胶基和香味剂，这些百分比基于口香糖组合物各区域的重量。 这种口香糖具有更强的风味冲击力和快速持续的风味释放特性。
• A chewing gum composition, a process for preparing a chewing gum tablet therefrom, and a chewing gum tablet
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0151344A2

  公开（公告）日：1985-08-14

  A chewing gum composition suitable for use in the preparation of a chewing gum tablet, the gum composition comprising a blended mixture of: chewing gum granules which comprise a chewing gum base, a grinding aid and a sweetening agent; and a compression aid which comprises two or more components chosen from a lubricant, a glidant and an anti-adherent; wherein the gum composition has a moisture content of from 2% to 8% by weight of the gum composition. Additionally, a process for producing a chewing gum tablet is disclosed. The tabletted compositions may contain one or more medicament.

  一种适用于制备口香糖片剂的口香糖组合物，该口香糖组合物包括以下物质的混合混合物：口香糖颗粒，该颗粒包括口香糖基质、研磨助剂和甜味剂；以及压缩助剂，该压缩助剂包括从润滑剂、滑润剂和防粘剂中选出的两种或两种以上成分；其中，按口香糖组合物的重量计，该口香糖组合物的水分含量为2%至8%。 此外，还公开了一种生产口香糖片剂的工艺。 片剂组合物可含有一种或多种药物。
• Novel pharmaceutical compositions comprising analgesic agents or caffeine
  申请人：SUNSHINE, Abraham

  公开号：EP0229022A2

  公开（公告）日：1987-07-15

  Novel analgesic compositions for use in eliciting an analgesic response, said compositions comprising caffeine together with a selected non-narcotic analgesic/non-steroidal anti-inflammatory drug or a selected narcotic analgesic, or both, are disclosed. When used in combination with the selected drugs, caffeine enhances the analgesic response and also hastens its onset.

  本发明公开了用于引起镇痛反应的新型镇痛组合物，所述组合物由咖啡因与所选的非麻醉性镇痛药/非甾体抗炎药或所选的麻醉性镇痛药或两者共同组成。当咖啡因与所选药物结合使用时，咖啡因会增强镇痛反应，并加速镇痛反应的发生。
• Stabilized solid pharmaceutical preparation containing dextromethorphan, phenylpropanolamine and caffeine
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0631782A1

  公开（公告）日：1995-01-04

  To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredients into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid pharmaceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingredients are stabilized for a longer period of time.

  为了稳定活性成分，咖啡因被加入到由右美沙芬和苯丙醇胺组成的固体药物制剂中。药物制剂还可进一步包含布洛芬。在掺入咖啡因的同时，还可通过将每种或适当组合的多种活性成分分别分组并掺入不同的组中，或通过尽量减少任何还原糖（如乳糖）的用量，来进一步稳定活性成分。这种固体药物制剂具有很高的实用价值，因为每种有效成分随着时间的推移而分解的现象明显减少，有效成分的稳定时间也更长。
• SACCHARIDE-CONTAINING COMPOSITIONS
  申请人：FUJI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1008353A1

  公开（公告）日：2000-06-14

  Spray-dried powders containing calcium hydrogen phosphate and saccharides having excellent powder-fluidity and compression-moldability, being quickly disintegrated/dissolved when put into the oral cavity or water in the form of granules, tablets, etc., being useful as fillers, compression-moldability improvers, disintegration aids, administration-facilitating agents, solubilizers in the oral cavity, etc. and being applicable to drugs, foods, etc.

  含有磷酸氢钙和糖类的喷雾干燥粉末，具有极佳的粉末流动性和压模性，以颗粒、片剂等形式放入口腔或水中时可迅速崩解/溶解，可用作填充剂、压模性改进剂、崩解辅助剂、给药促进剂、口腔增溶剂等，适用于药物、食品等。