α,α'-dimethyldiphenethylamine | 10509-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α,α'-dimethyldiphenethylamine
• 英文别名: bis(1-phenyl-2-propyl)amine；1-phenyl-N-(1-phenylpropan-2-yl)propan-2-amine
• CAS: 10509-86-1
• 化学式: C₁₈H₂₃N
• 分子量: 253.387
• InChiKey: XIZFJFZATSHCAL-UHFFFAOYSA-N

物化性质

• 沸点：
  154 °C(Press: 2 Torr)
• 密度：
  0.980±0.06 g/cm3(Predicted)
• 保留指数：
  1867.9;1873.6

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-苯基-2-丙醇 在 [Cp*Ir(NH₃)3]I₂ 、 氨 作用下， 以 水 为溶剂， 反应 24.0h， 以81%的产率得到α,α'-dimethyldiphenethylamine
  参考文献：
  名称：

  Multialkylation of Aqueous Ammonia with Alcohols Catalyzed by Water-Soluble Cp*Ir−Ammine Complexes

  摘要：

  Novel water-soluble Cp*Ir-ammine complexes have been synthesized, and a new and highly atom-economical system for the synthesis of organic amines using aqueous ammonia as a nitrogen source has been developed. With a water-soluble and air-stable Cp*Ir-ammine catalyst, [Cp*Ir(NH3)(3)][1](2), a variety of tertiary and secondary amines were synthesized by the multialkylation of aqueous ammonia with theoretical equivalents of primary and secondary alcohols. The catalyst could be recycled by a facile procedure maintaining high activity. A one-flask synthesis of quinolizidine starting with 1,5,9-nonanetriol was also demonstrated. This new catalytic system would provide a practical and environmentally benign methodology for the synthesis of various organic amines.

  DOI：

  10.1021/ja107274w

文献信息

• Characterization of Route Specific Impurities Found in Methamphetamine Synthesized by the Leuckart and Reductive Amination Methods
  作者：Vanitha Kunalan、Niamh Nic Daéid、William J. Kerr、Hilary A. S. Buchanan、Allan R. McPherson

  DOI：10.1021/ac9005588

  日期：2009.9.1

  Impurity profiling of seized methamphetamine can provide very useful information in criminal investigations and, specifically, on drug trafficking routes, sources of supply, and relationships between seizures. Particularly important is the identification of “route specific” impurities or those which indicate the synthetic method used for manufacture in illicit laboratories. Previous researchers have

  缉获的甲基苯丙胺杂质分析可为刑事调查提供非常有用的信息，特别是关于贩毒路线、供应来源和缉获之间关系的信息。特别重要的是识别“特定路线”杂质或那些表明在非法实验室制造时使用的合成方法的杂质。以前的研究人员提出了 Leuckart 和还原胺化 (Al/Hg) 制备方法所特有的杂质。然而，迄今为止，重要的是，这两种合成方法尚未在使用内部合成的盐酸甲基苯丙胺的单一研究中进行比较，因此具有已知的合成来源。使用相同的原料，1-苯基-2-丙酮（P2P），通过Leuckart和还原胺化方法合成了40批甲基苯丙胺盐酸盐（每种方法20批）。分别提取碱性和酸性杂质并通过 GC/MS 进行分析。从该对照研究中，报告了 Leuckart 方法的两种路线特定杂质和还原胺化方法的一种路线特定杂质。评估了这些途径特定杂质的批内和批间变化。此外，最近推荐用于甲基苯丙胺分析的“目标杂质”的变化与它们在使用 Leuckart
• Krasik Pavel, Alper Howard, Tetrahedron: Asymmetry, 3 (1992) N 10, S 1283-1288
  作者：Krasik Pavel, Alper Howard

  DOI：——

  日期：——
• PREPARATION METHOD OF OLIGOMER ADDITIVE, OLIGOMER ADDITIVE, AND LITHIUM BATTERY
  申请人：National Taiwan University of Science and Technology

  公开号：US20190248958A1

  公开（公告）日：2019-08-15

  A preparation method of an oligomer additive including the following steps is provided. A compound (A) having a secondary amine and a basic compound (B) are reacted. Next, a product of the reaction and a compound (C) having an unsaturated carbon-carbon double bond are reacted in a solvent. When the oligomer additive prepared by the method is applied in the cathode of a lithium battery, the cathode electrode core structure can be effectively protected from an environment condition such as high temperature, droppage, or deformation by external force. Moreover, the lithium battery cycle life can be maintained.
• Multialkylation of Aqueous Ammonia with Alcohols Catalyzed by Water-Soluble Cp*Ir−Ammine Complexes
  作者：Ryoko Kawahara、Ken-ichi Fujita、Ryohei Yamaguchi

  DOI：10.1021/ja107274w

  日期：2010.11.3

  Novel water-soluble Cp*Ir-ammine complexes have been synthesized, and a new and highly atom-economical system for the synthesis of organic amines using aqueous ammonia as a nitrogen source has been developed. With a water-soluble and air-stable Cp*Ir-ammine catalyst, [Cp*Ir(NH3)(3)][1](2), a variety of tertiary and secondary amines were synthesized by the multialkylation of aqueous ammonia with theoretical equivalents of primary and secondary alcohols. The catalyst could be recycled by a facile procedure maintaining high activity. A one-flask synthesis of quinolizidine starting with 1,5,9-nonanetriol was also demonstrated. This new catalytic system would provide a practical and environmentally benign methodology for the synthesis of various organic amines.