Butane-1-sulfonic acid (1-methyl-2-phenyl-ethyl)-amide | 50821-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Butane-1-sulfonic acid (1-methyl-2-phenyl-ethyl)-amide
• 英文别名: N-(1-phenylpropan-2-yl)butane-1-sulfonamide
• CAS: 50821-70-0
• 化学式: C₁₃H₂₁NO₂S
• 分子量: 255.381
• InChiKey: DPOOCFVIKTWPQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-丁基磺酰氯 、 非那明 以 苯 为溶剂， 生成 Butane-1-sulfonic acid (1-methyl-2-phenyl-ethyl)-amide
  参考文献：
  名称：

  外用驱蚊剂。VI。磺酰胺和喹啉-4-羧酸衍生物。

  摘要：

  DOI：

  10.1002/jps.2600620543

文献信息

• Sulfonamide derivatives
  申请人：——

  公开号：US20030225266A1

  公开（公告）日：2003-12-04

  The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

  本发明提供了一些磺胺衍生物，可用于增强患者的谷氨酸受体功能，因此可用于治疗多种疾病，如精神疾病和神经系统疾病。
• (BIS)sulfonamide derivatives
  申请人：——

  公开号：US20040054009A1

  公开（公告）日：2004-03-18

  The present invention provides (bis) sulfonamide derivatives of formula (I) useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

  本发明提供了公式(I)的(双)磺胺衍生物，可用于增强哺乳动物的谷氨酸受体功能，因此可用于治疗多种疾病，如精神疾病和神经系统疾病。
• [EN] N-SUBSTITUTED SULFONAMIDE DERIVATIVES<br/>[FR] SULFAMIDES N-SUBSTITUES
  申请人：LILLY CO ELI

  公开号：WO2000006537A1

  公开（公告）日：2000-02-10

  The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

  本发明提供了一些N-取代磺酰胺衍生物，用于增强哺乳动物的谷氨酸受体功能，因此，用于治疗广泛的疾病，如精神和神经系统疾病。
• Sulphonamide derivatives
  申请人：——

  公开号：US20020002158A1

  公开（公告）日：2002-01-03

  Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula R 1 —L—NHSO 2 R 2 I in which R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R 3 R 4 N in which R 3 and R 4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring; and pharmaceutically acceptable salts thereof. Also disclosed are novel compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

  一种具有公式R1-L-NHSO2R2的化合物的有效量可以增强哺乳动物中的谷氨酸受体功能，其中R1表示未取代或取代的芳香或杂环芳香基团；R2表示（1-6C）烷基，（3-6C）环烷基，（1-6C）氟烷基，（1-6C）氯烷基，（2-6C）烯基，（1-4C）烷氧基（1-4C）烷基，苯基，该苯基未取代或通过卤素，（1-4C）烷基或（1-4C）烷氧基取代，或公式R3R4N的基团，其中R3和R4各自独立地表示（1-4C）烷基，或者与它们所连接的氮原子一起形成一个氮杂环基团，包括氮杂丙环基团，吡咯环基团，哌啶环基团，吗啉环基团，哌嗪环基团，六氢氮杂环基团或八氢氮杂环基团；L表示未取代或通过（1-6C）烷基，芳基（1-6C）烷基，（2-6C）烯基，芳基（2-6C）烯基和芳基中选择的一种或两种独立选择的取代基取代的（2-4C）烷基链，或者通过两种取代基与它们所连接的碳原子或碳原子一起形成一个（3-8C）碳环；以及其药学上可接受的盐。还公开了公式I的新化合物，制备它们的过程以及包含它们的制药组合物。
• SULPHONAMIDE DERIVATIVES
  申请人：Arnold B. Macklin

  公开号：US20060030599A1

  公开（公告）日：2006-02-09

  Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula R 1 -L-NHSO 2 R 2 I in which R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C) chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R 3 R 4 N in which R 3 and R 4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring; and pharmaceutically acceptable salts thereof. Also disclosed are novel compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

  一种化合物可以增强哺乳动物中谷氨酸受体的功能，该化合物的化学式为R1-L-NHSO2R2，其中R1表示未取代或取代的芳香或杂芳基团；R2表示(1-6C)烷基，(3-6C)环烷基，(1-6C)氟代烷基，(1-6C)氯代烷基，(2-6C)烯基，(1-4C)烷氧基(1-4C)烷基，苯基，未取代或取代的卤素、(1-4C)烷基或(1-4C)烷氧基，或者公式R3R4N的基团，其中R3和R4各自独立地表示(1-4C)烷基，或者与它们连接的氮原子一起形成氮杂环丙烷基、吡咯烷基、哌啶基、吗啉基、哌嗪基、六氢氮杂环庚烷基或八氢氮杂环二十烷基；L表示未取代或取代的(2-4C)烷基链，该链通过一个或两个独立选择的取代基未取代或取代，这些取代基是(1-6C)烷基，芳基(1-6C)烷基，(2-6C)烯基芳基(2-6C)烯基芳基，或者通过两个取代基与它们连接的碳原子或碳原子形成(3-8C)环状碳基环；以及其药学上可接受的盐。还公开了公式I的新化合物，制备它们的方法以及含有它们的制药组合物。