bisacetophenone-o-phenylenediamine | 129880-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bisacetophenone-o-phenylenediamine
• 英文别名: N,N'-bis(1-phenyl-ethylidene)benzene-1,2-diamine；bpebd；N,N'-bis-(1-phenyl-ethylidene)-benzene-1,2-diamine；1-phenyl-N-[2-(1-phenylethylideneamino)phenyl]ethanimine
• CAS: 129880-62-2
• 化学式: C₂₂H₂₀N₂
• 分子量: 312.414
• InChiKey: PFCURHIIXBZZGG-UHFFFAOYSA-N

物化性质

• 熔点：
  124-126 °C
• 沸点：
  441.1±41.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bisacetophenone-o-phenylenediamine 在 (2-biphenyl)Cy₂PAuNTf₂ 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以95%的产率得到2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine
  参考文献：
  名称：

  Gold(I)-Catalyzed Synthesis of 1,5-Benzodiazepines Directly from o-Phenylenediamines and Alkynes

  摘要：

  A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.

  DOI：

  10.1021/jo300543n
• 作为产物：
  描述：

  苯乙酮 、 邻苯二胺 以 乙醇 为溶剂， 反应 8.0h， 生成 bisacetophenone-o-phenylenediamine
  参考文献：
  名称：

  Interaction of drug based binuclear mixed-ligand complexes with DNA

  摘要：

  Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram(( ve)) organisms. Interaction of the complexes with nucleic acid (DNA) were investigated using spectroscopic technique, viscosity measurement and gel electrophoresis and it was found that the complexes bind to DNA via intercalative mode. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.06.023

文献信息

• Srivastava; Srivastava; Sharma, Journal of the Indian Chemical Society, 1990, vol. 67, # 4, p. 310 - 312
  作者：Srivastava、Srivastava、Sharma

  DOI：——

  日期：——
• Ahmed, Dildar; Mir, Hira, Journal of the Chemical Society of Pakistan, 2014, vol. 36, # 5, p. 915 - 921
  作者：Ahmed, Dildar、Mir, Hira

  DOI：——

  日期：——
• Gold(I)-Catalyzed Synthesis of 1,5-Benzodiazepines Directly from <i>o</i>-Phenylenediamines and Alkynes
  作者：Jianqiang Qian、Yunkui Liu、Jianhai Cui、Zhenyuan Xu

  DOI：10.1021/jo300543n

  日期：2012.5.4

  A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.
• Interaction of drug based binuclear mixed-ligand complexes with DNA
  作者：Mohan N. Patel、Mehulsinh R. Chhasatia、Deepen S. Gandhi

  DOI：10.1016/j.bmc.2009.06.023

  日期：2009.8

  Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram(( ve)) organisms. Interaction of the complexes with nucleic acid (DNA) were investigated using spectroscopic technique, viscosity measurement and gel electrophoresis and it was found that the complexes bind to DNA via intercalative mode. (C) 2009 Elsevier Ltd. All rights reserved.