1-Amino-2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)naphthalene | 1992-25-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Amino-2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)naphthalene
• 英文别名: 2-(1-amino-naphthalen-2-yl)-1,1,1,3,3,3-hexafluoro-propan-2-ol；1-Amino-2-(hexafluor-2-hydroxy-2-propyl)-naphthalin；2-(1-Aminonaphthalen-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS: 1992-25-2
• 化学式: C₁₃H₉F₆NO
• 分子量: 309.211
• InChiKey: LBOTVCGVALXEGK-UHFFFAOYSA-N

物化性质

• 熔点：
  164.5-165.5 °C
• 沸点：
  387.1±42.0 °C(Predicted)
• 密度：
  1.498±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-Amino-2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)naphthalene 在 溴 、 sodium acetate 作用下， 生成 N-[4-Bromo-2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-acetamide
  参考文献：
  名称：

  Structure–activity relationship of a novel class of naphthyl amide KATP channel openers

  摘要：

  We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K-ATP channels and investigated structure-activity relationships (SAR) around the 1,2-disubstituted naphthyl core. A-151892, a prototype compound of this series, was found to be a potent and efficacious potassium channel opener in vitro in transfected Kir6.2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00205-1
• 作为产物：
  描述：

  1-萘胺 、 六氟丙酮 在 对甲苯磺酸 作用下， 生成 1-Amino-2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)naphthalene
  参考文献：
  名称：

  Structure–activity relationship of a novel class of naphthyl amide KATP channel openers

  摘要：

  We have discovered a novel series of N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl] amides that are potent openers of K-ATP channels and investigated structure-activity relationships (SAR) around the 1,2-disubstituted naphthyl core. A-151892, a prototype compound of this series, was found to be a potent and efficacious potassium channel opener in vitro in transfected Kir6.2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00205-1

文献信息

• Naphthalene amides as potassium channel openers
  申请人：——

  公开号：US20030199578A1

  公开（公告）日：2003-10-23

  The present invention relates to compounds and their ability to act as potassium channel openers.

  本发明涉及化合物及其作为钾通道开放剂的能力。
• Reactions of highly electrophilic polyfluorocarbonyl compounds with primary arylamines
  作者：N. D. Chkanikov、V. D. Sviridov、A. E. Zelenin、M. V. Galakhov、A. F. Kolomiets、A. V. Fokin

  DOI：10.1007/bf00960662

  日期：1990.2
• CHKANIKOV, N. D.;SVIRIDOV, V. D.;ZELENIN, A. E.;GALAXOV, M. V.;KOLOMIETS,+, IZV. AN CCCP. CEP. XIM.,(1990) N, S. 383-389
  作者：CHKANIKOV, N. D.、SVIRIDOV, V. D.、ZELENIN, A. E.、GALAXOV, M. V.、KOLOMIETS,+

  DOI：——

  日期：——
• Formulation to improve survival of transplanted cells
  申请人：Murry E. Charles

  公开号：US20070166288A1

  公开（公告）日：2007-07-19

  The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that enhance survival, and may be heat shocked prior to transplantation.
• [EN] NAPHTHALENE AMIDES AS POTASSIUM CHANNEL OPENERS<br/>[FR] AMIDES DU NAPHTALENE UTILISES COMME AGENTS D'OUVERTURE DU CANAL POTASSIQUE
  申请人：ABBOTT LAB

  公开号：WO2003089404A1

  公开（公告）日：2003-10-30

  The present invention relates to naphthylamide compounds and their ability to act as potassium channel openers.