1,2-didehydro-1,4,5,6,7,8,9,10-octahydro-[1,3]diazecine | 6543-91-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-didehydro-1,4,5,6,7,8,9,10-octahydro-[1,3]diazecine
• 英文别名: 4H-2δ²-[1,3]diazecine；1,3-Diaza-cyclodeca-1,2-dien；Heptamethylencarbodiimid
• CAS: 6543-91-5；72995-05-2
• 化学式: C₈H₁₄N₂
• 分子量: 138.213
• InChiKey: PRBXUOBJHAOJJM-UHFFFAOYSA-N

物化性质

• 沸点：
  190.7±7.0 °C(Predicted)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-didehydro-1,4,5,6,7,8,9,10-octahydro-[1,3]diazecine 在 水 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 、 丙酮 为溶剂， 反应 38.0h， 生成 1,7-heptamethylene diisocyanate
  参考文献：
  名称：

  1,13-Diazabicyclo[11.1.1]pentadecane-14.15-dione and 1,12-diazabicyclo[10.1.1]tetradecane-13,14 dione. Two novel aliphatic diisocyanate dimers

  摘要：

  DOI：

  10.1021/jo00338a038
• 作为产物：
  描述：

  1,3-Diazecane-2-thione 在 二氯甲烷 、 mercury(II) oxide 作用下， 生成 1,2-didehydro-1,4,5,6,7,8,9,10-octahydro-[1,3]diazecine
  参考文献：
  名称：

  Behringer; Meier, Justus Liebigs Annalen der Chemie, 1957, vol. 607, p. 67,76

  摘要：

  DOI：

文献信息

• COMPOUNDS HAVING GUANIDINE GROUPS AND CONTAINING SEMI-ORGANIC SILICON GROUPS
  申请人：Evonik Degussa GmbH

  公开号：US20150057412A1

  公开（公告）日：2015-02-26

  This invention relates to compounds having guanidine groups and containing semi-organic silicon groups, their use for the curing of compounds containing alkoxysilyl groups, compositions comprising the curing catalysts of the invention, and use of the compositions as adhesives and sealants and also as coating materials.

  这项发明涉及具有胍基团和含有半有机硅基团的化合物，它们用于固化含有烷氧基硅基团的化合物，包括本发明的固化催化剂的组合物，以及将这些组合物用作粘合剂、密封剂和涂料材料的用途。
• Synthetic chondroitin sulfate proteoglycan and process for producing the same
  申请人：SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION)

  公开号：EP0466966A1

  公开（公告）日：1992-01-22

  57 A synthetic chondroitin sulfate proteoglycan containing chondroitin sulfate and serum albumin chemically bound thereto, which inhibits the adhesion of various types of cells to fibronectin and related substances and a process for producing the same comprising binding chondroitin sulfate to serum albumin by a carbodiimide condensation method or a cyanogen bromide activation-method.

  57 一种合成的硫酸软骨素蛋白多糖，含有硫酸软骨素和与其化学结合的血清白蛋白，可抑制各种细胞对纤维粘连蛋白和相关物质的粘附；以及一种生产硫酸软骨素蛋白多糖的工艺，包括通过碳二亚胺缩合法或溴化氰活化法将硫酸软骨素与血清白蛋白结合。
• Agent for forming spheroids of hepatocytes and process for culturing hepatocytes for formation of spheroids
  申请人：SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION)

  公开号：EP0529659A2

  公开（公告）日：1993-03-03

  An agent for the formation of spheroids of hepatocytes, which comprises a covalently lipid-bound glycosaminoglycan, and a culturing process for the formation of the spheroids. Hepatocytes spheroids can be formed by culturing hepatocytes in a culture vessel using a lipid-bound glycosaminoglycan as a culture substrate. Floating spheroids of hepatocytes can be obtained efficiently, which are capable of maintaining liver-specific functions and of keeping the spheroid form stably for a prolonged period of time.

  一种用于形成肝细胞球形体的制剂，它包括一种共价脂质结合的氨基糖，以及一种用于形成球形体的培养工艺。 肝细胞球可以通过在培养容器中使用脂质结合糖胺聚糖作为培养基质培养肝细胞来形成。可以有效地获得漂浮的肝细胞球体，这种球体能够保持肝脏的特异功能，并能长期稳定地保持球体形态。
• PEPTIDE WITH ACTIVITY OF INHIBITING CANCER CELL INFILTRATION, COMPOSITE THEREOF, AND CANCER METASTASIS INHIBITOR
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0513388A1

  公开（公告）日：1992-11-19

  A peptide having an activity of inhibiting cancer cell infiltration and containing 5 to 20 amino acid residues, preferably any of those having amino acid sequences (1) to (13); and a cancer metastasis inhibitor containing the peptide as the active ingredient. A peptide composite comprising a peptide having an activity of inhibiting cancer cell infiltration and a biopolymer chemically bonded thereto, wherein the peptide is preferably any of those having amino acid sequences (1) to (14) and the biopolymer is preferably a protein such as albumin or globulin; and a cancer metastasis inhibitor containing the peptide composite as the active ingredient. The amino acid sequences (1) to (14) wherein, Glx represents Glu or Gln, and Asx represents Asn or Asp.

  一种多肽，具有抑制癌细胞浸润的活性，含有5至20个氨基酸残基，优选具有氨基酸序列(1)至(13)中的任一氨基酸残基；以及一种癌症转移抑制剂，含有该多肽作为活性成分。一种多肽复合制剂，包括具有抑制癌细胞浸润活性的多肽和与其化学键合的生物聚合物，其中多肽优选具有氨基酸序列（1）至（14）的任何一种，生物聚合物优选蛋白质，如白蛋白或球蛋白；以及一种含有该多肽复合制剂作为活性成分的癌症转移抑制剂。氨基酸序列(1)至(14) 其中，Glx 代表 Glu 或 Gln，Asx 代表 Asn 或 Asp。
• Tumor cell invasion-inhibiting peptides and cancer metastasis inhibitors
  申请人：ASAHI GLASS COMPANY LTD.

  公开号：EP0671412A1

  公开（公告）日：1995-09-13

  The present invention is a peptide having from 5 to 20 amino acid residues having tumor cell invasion-inhibiting activities. As such a peptide, a peptide represented by any one of the formulas (1) to (13) is preferred among peptides having the following amino acid sequences. Further, the present invention is a cancer metastasis inhibitor comprising the above peptide as an active ingredient. Still further, the present invention is a cancer metastasis inhibitor comprising the above peptide complex as an active ingredient.    (1) Ala-Glx-Lys-Ala-Glx-Gly    (2) Ala-Glx-Lys-Ala-Glx-Gly-Ala    (3) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly    (4) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx    (5) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx-Ala    (6) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx-Ala-Lys    (7) Asx-Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly    (8) Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly    (9) Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly    (10) Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly    (11) Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly    (12) Glx-Ala-Glx-Lys-Ala-Glx-Gly    (13) Asx-Glx-Ala-Glx-Lys-Ala wherein Glx is Glu or Gln, and Asx is Asn or Asp.

  本发明是一种具有 5 至 20 个氨基酸残基、具有肿瘤细胞侵袭抑制活性的多肽。作为这样的多肽，在具有以下氨基酸序列的多肽中，优选由式（1）至（13）中的任意一个表示的多肽。 更进一步，本发明是一种包含上述多肽作为活性成分的癌症转移抑制剂。 更进一步，本发明是一种包含上述多肽复合物作为活性成分的癌症转移抑制剂。 (1) Ala-Glx-Lys-Ala-Glx-Gly (2) Ala-Glx-Lys-Ala-Glx-Gly-Ala (3) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly (4) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx (5) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx-Ala (6) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx-Ala-Lys (7) Asx-Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (8) Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (9) Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (10) Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (11) Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (12) Glx-Ala-Glx-Lys-Ala-Glx-Gly (13) Asx-Glx-Ala-Glx-Lys-Ala 其中 Glx 为 Glu 或 Gln，Asx 为 Asn 或 Asp。