7α-hydroxy-3,12-dioxo-23,24-dinorchol-4-enoic acid | 13550-04-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7α-hydroxy-3,12-dioxo-23,24-dinorchol-4-enoic acid
• 英文别名: 7α-hydroxy-3,12-dioxo-23,24-dinor-chol-4-en-22-oic acid；7α-Hydroxy-3,12-dioxo-23,24-dinor-chol-4-en-22-saeure
• CAS: 13550-04-4
• 化学式: C₂₂H₃₀O₅
• 分子量: 374.5
• InChiKey: SCUKZAGRSCWQEL-DGBUQYAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7α-hydroxy-3,12-dioxo-23,24-dinorchol-4-enoic acid 在 氢氧化钾 作用下， 生成 3,12-dioxo-23,24-dinorchola-4,6-dienoic acid
  参考文献：
  名称：

  Adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings

  摘要：

  Background: Acquired neoplasms arising from the nonpigmented ciliary epithelium (NPCE) are much less common than uveal melanocytic proliferations. We report two cases of acquired neoplasms arising from the NPCE with immunohistochemical findings. Methods: Case reports. Results and conclusions: Patient 1 was a 39-year-old man who presented with a pigmented mass behind the iris and secondary exudative retinal detachment. The eye also developed neovascular glaucoma. Patient 2 was a 44-year-old woman with a ciliary body mass but without symptoms. Both of these tumors were classified histologically as low-grade adenocarcinomas of the NPCE from specimens successfully removed by iridocyclectomy. Immunohistochemical findings confirmed the origin of the tumor cells. however. some changes in the immunoreactivity to cytokeratin AE1 and epithelial membrane antigen were found.

  DOI：

  10.1007/s004170100353
• 作为产物：
  描述：

  去氢胆酸 在 aspergillus cinnamomeus 作用下， 生成 7α-hydroxy-3,12-dioxo-23,24-dinorchol-4-enoic acid
  参考文献：
  名称：

  Hasegawa, Hiroshima Journal of Medical Sciences, 1959, vol. 8, p. 271,272

  摘要：

  DOI：

文献信息

• Hayakawa, Proceedings of the Japan Academy, 1954, vol. 30, p. 133,134
  作者：Hayakawa

  DOI：——

  日期：——
• MICROBIOLOGICAL DEGRADATION OF BILE ACIDS
  作者：YASUO SABURI、SHOHEI HAYAKAWA、TAKAO FUJII、IKURO AKAEDA

  DOI：10.1093/oxfordjournals.jbchem.a126675

  日期：1956.9