Ethyl 3-(cyanomethyl)piperidine-3-carboxylate | 1359818-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Ethyl 3-(cyanomethyl)piperidine-3-carboxylate
• 英文别名: ethyl 3-(cyanomethyl)piperidine-3-carboxylate
• CAS: 1359818-75-9
• 化学式: C₁₀H₁₆N₂O₂
• 分子量: 196.249
• InChiKey: WTYMURXSDWZZNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 3-(cyanomethyl)piperidine-3-carboxylate 在 氨 、 氢气 、 三乙酰氧基硼氢化钠 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 tert-butyl 4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidine-1-carboxylate
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

  摘要：

  Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the spiro-lactone ring and the benzothiophene portion of the molecule. Spiro-imide derivative 8c containing a 6-methylthieno[2,3-b]pyridine core exhibited potent ACC inhibitory activity and favorable pharmacokinetic profiles in rats. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.047
• 作为产物：
  描述：

  N-Boc-3-哌啶甲酸乙酯 在 盐酸 、 lithium hexamethyldisilazane 作用下， 以 乙酸乙酯 为溶剂， 生成 Ethyl 3-(cyanomethyl)piperidine-3-carboxylate
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

  摘要：

  Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the spiro-lactone ring and the benzothiophene portion of the molecule. Spiro-imide derivative 8c containing a 6-methylthieno[2,3-b]pyridine core exhibited potent ACC inhibitory activity and favorable pharmacokinetic profiles in rats. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.047

文献信息

• Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors
  作者：Makoto Kamata、Tohru Yamashita、Asato Kina、Masaaki Funata、Atsushi Mizukami、Masako Sasaki、Akiyoshi Tani、Miyuki Funami、Nobuyuki Amano、Kohji Fukatsu

  DOI：10.1016/j.bmcl.2012.04.047

  日期：2012.6

  Spiro-lactone (S)-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor and was found to be metabolically liable in human hepatic microsomes. To remove one of the risk factors in human study by improving the metabolic stability, we focused on modifying the spiro-lactone ring and the benzothiophene portion of the molecule. Spiro-imide derivative 8c containing a 6-methylthieno[2,3-b]pyridine core exhibited potent ACC inhibitory activity and favorable pharmacokinetic profiles in rats. (C) 2012 Elsevier Ltd. All rights reserved.