4-oxa-1-azabicyclo-<3.3.0>octane | 6040-01-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-oxa-1-azabicyclo-<3.3.0>octane
• 英文别名: hexahydro-pyrrolo[2,1-b]oxazole；4-Oxa-1-aza-bicyclo<3.3.0>octan；4-Oxa-1-azabicyclo<3,30>octan；Oxapyrrolizidine；2,3,5,6,7,7a-hexahydropyrrolo[2,1-b][1,3]oxazole
• CAS: 6040-01-3
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: RRQLLPCYRAISML-UHFFFAOYSA-N

物化性质

• 沸点：
  52 °C(Press: 15 Torr)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-羟乙基)-吡咯烷 在 萘-1,4-二腈 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以70%的产率得到4-oxa-1-azabicyclo-<3.3.0>octane
  参考文献：
  名称：

  通过光敏（固定）氧化反应生成亚胺阳离子的新型选择性方法

  摘要：

  报道了一种通过光敏单电子转移过程生成亚胺阳离子的新方法及其通过氧和碳亲核试剂进行分子内环化的方法。

  DOI：

  10.1016/s0040-4039(00)80442-6

文献信息

• [EN] THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE<br/>[FR] DÉRIVÉ DE THIÉNOPYRIMIDINE ET SON UTILISATION EN MÉDECINE
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2018133858A1

  公开（公告）日：2018-07-26

  The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

  本发明涉及一种噻吡嘧啶衍生物及其在医学上的用途，以及含有该化合物的药物组合物。该化合物或药物组合物用于抑制乙酰辅酶A羧化酶（ACC）。本发明还涉及一种制备该化合物和药物组合物的方法，以及它们在哺乳动物，特别是人类中治疗或预防由乙酰辅酶A羧化酶调节的疾病的用途。
• Regioselective generation of iminium cation by PET processes: Its in situ trapping by intramolecular nucleophiles and synthesis of some biologically active heterocycles.
  作者：Ganesh Pandey、G. Kumaraswamy、P.Yella Reddy

  DOI：10.1016/s0040-4020(01)80497-x

  日期：1992.1

  Efficient, mild and direct route for regiospecific iminium cation is developed by sequential two electron oxidation of several N-alkylated tertiary amines by photoinduced electron transfer processes. The regiospecificity of iminium cation arises from the deprotonation step of amine radical cation to generate α-amino radical which depends on the stereoelectronic factor subject to kinetic acidity of

  通过光诱导的电子转移过程，对几个N-烷基化的叔胺进行连续的两次电子氧化，从而开发出了高效，温和且直接的区域特异性亚胺阳离子途径。亚胺阳离子的区域特异性来自胺自由基阳离子的去质子化步骤以产生α-氨基自由基，该α-氨基自由基取决于受胺自由基阳离子的动力学酸度影响的立体电子因子。亚铵阳离子被有效地俘获原位通过内部nuleophiles，得到环状化合物14-18和22A-C 。顺式α，α'-二烷基化哌啶和吡咯烷30a–c的立体选择性合成是通过亲和性打开四氢-1,3-恶嗪22a–c实现的。
• Thienopyrimidine derivative and use thereof in medicine
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US10759812B2

  公开（公告）日：2020-09-01

  The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

  本发明涉及一种噻吩嘧啶衍生物及其在医学中的用途，还涉及一种含有该化合物的药物组合物。该化合物或药物组合物用于抑制乙酰-CoA 羧化酶（ACC）。本发明还涉及制备这种化合物和药物组合物的方法，以及它们在治疗或预防哺乳动物，特别是人类受乙酰-CoA 羧化酶调节的疾病中的用途。
• Thienopyrimidine derivatives as ACC inhibitors and uses thereof
  申请人：Gilead Sciences, Inc.

  公开号：US11352371B2

  公开（公告）日：2022-06-07

  The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

  本公开一般涉及与乙酰-CoA 羧化酶（ACC）结合并作为 ACC 抑制剂的噻吩嘧啶化合物。本公开进一步涉及噻吩嘧啶化合物用于制备通过与 ACC 结合治疗疾病和/或病症的药物，包括肝脏疾病，如非酒精性脂肪肝（NAFLD）和非酒精性脂肪性肝炎（NASH）。
• Unsaturated Amines. XVI. An Oxidative Cyclization Route to Oxazolidines and Tetrahydro-1,3-oxazines^1,2
  作者：Nelson J. Leonard、W. Kenneth Musker

  DOI：10.1021/ja01504a032

  日期：1960.10