N-tert-butyl-6-nitrospiro[1,4-dihydroquinoxaline-3,1'-cyclohexane]-2-imine | 1198593-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-tert-butyl-6-nitrospiro[1,4-dihydroquinoxaline-3,1'-cyclohexane]-2-imine
• CAS: 1198593-55-3
• 化学式: C₁₇H₂₄N₄O₂
• 分子量: 316.403
• InChiKey: NLYNFSSYUUNCSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  82.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异氰酸叔丁酯 、 环己酮 、 4-硝基邻苯二胺 在 ammonium cerium (IV) nitrate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以91%的产率得到N-tert-butyl-6-nitrospiro[1,4-dihydroquinoxaline-3,1'-cyclohexane]-2-imine
  参考文献：
  名称：

  CAN-catalyzed syntheses of 3,4-dihydroquinoxalin-2-amine derivatives based on isocyanides

  摘要：

  Starting from readily available o-phenylenediamines 1, ketones 2 and isocyanides 3, a variety of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives 4 were efficiently synthesized in the presence of catalytic amount of cerium(IV) ammonium nitrate at room temperature The flexibility of this protocol also opens a new route to the Structurally unique spirocyclic analogs when cyclic ketones are employed (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2009.09.022

文献信息

• CAN-catalyzed syntheses of 3,4-dihydroquinoxalin-2-amine derivatives based on isocyanides
  作者：Jian Li、Yuejin Liu、Chunju Li、Xueshun Jia

  DOI：10.1016/j.tetlet.2009.09.022

  日期：2009.11

  Starting from readily available o-phenylenediamines 1, ketones 2 and isocyanides 3, a variety of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives 4 were efficiently synthesized in the presence of catalytic amount of cerium(IV) ammonium nitrate at room temperature The flexibility of this protocol also opens a new route to the Structurally unique spirocyclic analogs when cyclic ketones are employed (C) 2009 Elsevier Ltd All rights reserved