(Z)-1-isopropylthio-1-hexene | 1443329-36-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (Z)-1-isopropylthio-1-hexene
• 英文别名: (Z)-1-propan-2-ylsulfanylhex-1-ene
• CAS: 1443329-36-9
• 化学式: C₉H₁₈S
• 分子量: 158.308
• InChiKey: DBMKZZGIIOSAJS-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  iso-propyl (hexa-1-ynyl) sulfide 在 Schwartz's reagent 、 水 、 氯化铵 作用下， 以 二氯甲烷 为溶剂， 以54%的产率得到(Z)-1-isopropylthio-1-hexene
  参考文献：
  名称：

  Stereoselective hydrozirconation of alkynylsulfide and regioselective synthesis of haloalkenyl sulfide via electrophile-switched halogenation of thioalkenyl zirconocene

  摘要：

  Stereoselective preparation of alkenyl sulfide was carried out via syn-hydrozirconation of the alkynyl sulfide. Regiochemistry of halogenation of the thioalkenyl zirconocene could be switched by different halides. alpha-Chloroalkenyl sulfide or beta-haloalkenyl sulfide (Br, I) could be obtained by the treatment of NCS or NBS (NIS), respectively. Possible mechanism of halogenation of the thioalkenyl zirconocene was set up herein. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.122

文献信息

• SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
  申请人：Old David W.

  公开号：US20100093729A1

  公开（公告）日：2010-04-15

  A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compounds are also disclosed.

  本文揭示了一种包含或其药用可接受的盐、前药或代谢产物的化合物。Y、A和B如本文所述。还公开了与这些化合物相关的方法、组合物和药物。
• SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
  申请人：Burk Robert M.

  公开号：US20090197962A1

  公开（公告）日：2009-08-06

  Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.

  本文揭示了治疗化合物、组合物、方法和相关药物。
• THERAPEUTIC COMPOUNDS
  申请人：Old David W.

  公开号：US20080015231A1

  公开（公告）日：2008-01-17

  A compound having a formula is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  本文披露了一种具有化学式的化合物。还披露了与之相关的治疗方法、组合物和药物。
• THERAPEUTIC AMIDES
  申请人：Old David W.

  公开号：US20080119539A1

  公开（公告）日：2008-05-22

  Compounds of the formula are disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  本文披露了公式的化合物。还披露了与其相关的治疗方法、组成物和药物。
• THERAPEUTIC N-ARYL OR N-HETEROARYL PYRAZOLIDINE AND PYRAZOLIDINONE DERIVATIVES
  申请人：Old W. David

  公开号：US20080045576A1

  公开（公告）日：2008-02-21

  A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.

  本文披露了一种具有结构的化合物及其相关的治疗方法、组合物和药物。