2-(6-Methyl-2-pyridyl)-1,3-dithiane | 108890-61-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(6-Methyl-2-pyridyl)-1,3-dithiane
• 英文别名: 2-(1,3-dithian-2-yl)-6-methylpyridine
• CAS: 108890-61-5
• 化学式: C₁₀H₁₃NS₂
• 分子量: 211.352
• InChiKey: OIYQJJURPHLNKD-UHFFFAOYSA-N

物化性质

• 熔点：
  68-70 °C
• 沸点：
  354.9±42.0 °C(predicted)
• 密度：
  1.180±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(6-Methyl-2-pyridyl)-1,3-dithiane 生成 [2-(6-methylpyridin-2-yl)-1,3-dithian-2-yl] ethanedithioate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-丙二硫醇 、 6-甲基-2-吡啶甲醛 在 silica gel-supported phosphorus pentoxide 作用下， 以94%的产率得到2-(6-Methyl-2-pyridyl)-1,3-dithiane
  参考文献：
  名称：

  Silica-supported phosphorus pentoxide: a reusable catalyst for S,S-acetalization of carbonyl groups under ambient conditions

  摘要：

  Phosphorus pentoxide supported on silica gel (P2O5/SiO2) efficiently acts as a highly active and reusable catalyst for cyclic and non-cyclic S,S-acetalization of a variety of carbonyl compounds under mild, solvent-free and ambient conditions. This method offers significant advantages such as high conversion, clean work-up, short reaction times and simplicity in operation.[GRAPHICS].

  DOI：

  10.1080/17415993.2010.542155

文献信息

• Thioformamide derivatives and use in inhibiting gastric secretion
  申请人：Rhone-Poulenc Sante

  公开号：US04680303A1

  公开（公告）日：1987-07-14

  Thioformamide derivatives of formula: ##STR1## in which R is hydrogen or alkyl (1 to 4 C), R.sub.1 is alkyl (1 to 4 C), and X denotes sulphur or oxygen and Y is sulphur, oxygen, methylene radical, or, when X is oxygen, a valency bond, are inhibitors of gastric secretion and therefore useful in the treatment of gastric ulcers. They may be made by reaction of an amine R--NH.sub.2 with a corresponding thioester or, when R is alkyl, by reaction of an alkyl isothiocyanate with the product of reacting a base with a compound of formula: ##STR2##

  公式为：##STR1## 的Thioformamide衍生物中，其中R为氢或烷基（1至4个碳原子），R.sub.1为烷基（1至4个碳原子），X表示硫或氧，Y为硫、氧、亚甲基基团或当X为氧时，为一个价键。它们是胃分泌抑制剂，因此在治疗胃溃疡方面很有用。它们可以通过将胺R-NH.sub.2与相应的硫酸酯反应或当R为烷基时，通过将烷基异硫氰酸酯与公式为##STR2##的化合物与碱反应所得的产物反应而制得。
• Molybdenum pentachloride (MoCl5) or molybdenum dichloride dioxide (MoO2Cl2): advanced catalysts for thioacetalization of heterocyclic, aromatic and aliphatic compounds
  作者：Shyamaprosad Goswami、Annada C. Maity

  DOI：10.1016/j.tetlet.2008.03.048

  日期：2008.5

  A new, convenient and mild method for thioacetalization of heterocyclic, aromatic and aliphatic compounds catalyzed by MoCl(5) or MoO(2)Cl(2) is described. This novel method is important for the synthesis of the difficult to prepare heterocyclic thioacetals such as the pterin thioacetals and it offers significant advantages such as high conversion, short reaction times and simplicity in operation. (C) 2008 Elsevier Ltd. All rights reserved.
• ——
  作者：ALOUP J. C.、 BOUCHAUDON J.、 FARGE D.、 JAMES C.

  DOI：——

  日期：——
• NEWKOME, GEORGE R.;LEE, H. W.;FRONCZEK, FRANK R., ISR. J. CHEM., 27,(1986) N 1, 87-95
  作者：NEWKOME, GEORGE R.、LEE, H. W.、FRONCZEK, FRANK R.

  DOI：——

  日期：——
• US4680303A
  申请人：——

  公开号：US4680303A

  公开（公告）日：1987-07-14