1-benzyl-2,4-dichlorobenzene | 65652-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-2,4-dichlorobenzene
• CAS: 65652-42-8
• 化学式: C₁₃H₁₀Cl₂
• 分子量: 237.128
• InChiKey: LQUWZOKGGJISJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-benzyl-2,4-dichlorobenzene 在 N-溴代丁二酰亚胺(NBS) 、 水 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以82%的产率得到2,4-二氯苯甲酮
  参考文献：
  名称：

  Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 CH oxidation

  摘要：

  Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on O-18-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.06.047
• 作为产物：
  描述：

  (2,4-二氯苯基)(苯基)甲醇 在 三氟化硼乙醚 作用下， 以 水 为溶剂， 反应 2.0h， 以53%的产率得到1-benzyl-2,4-dichlorobenzene
  参考文献：
  名称：

  BF 3 ·OEt 2中以醚为氢源促进了二苯甲醇，醚和酯还原为烃†

  摘要：

  已经描述了一种新颖的醚/ BF 3还原体系，其中二苯甲醇及其醚和酯衍生物被用作起始原料。还原反应是在乙醚中在回流和氩气气氛下进行的，加入额外的水有利于该还原反应。能够以良好或优异的产率制备一系列烷烃。氘代实验表明还原性氢是从醚中产生的。详细讨论了该机制以解释观察到的反应性。

  DOI：

  10.1039/c5ra14775a

文献信息

• Superacid BF₃–H₂O promoted benzylation of arenes with benzyl alcohols and acetates initiated by trace water
  作者：Shuting Zhang、Xiaohui Zhang、Xuege Ling、Chao He、Ruofeng Huang、Jing Pan、Jiaqiang Li、Yan Xiong

  DOI：10.1039/c4ra04059g

  日期：——

  An efficient in situ prepared superacid BF₃–H₂O promoted benzylation of arenes using benzyl alcohols and acetates achieves various diarylalkanes.

  一种高效的原位制备的超强酸BF3-H2O促进的芳烃苄基化反应，使用苄醇和醋酸酯制备各种二芳基烷烃。
• NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF
  申请人：CHOI Kyung Il

  公开号：US20090325979A1

  公开（公告）日：2009-12-31

  Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

  揭示了作为钙通道调节剂有用的新型咪唑基烷基羰基衍生物，以及其制备方法。还揭示了一种通过给予上述化合物进行治疗的方法，该方法基于它们对钙通道的抑制活性。
• NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF
  申请人：NAM Ghilsoo

  公开号：US20100094006A1

  公开（公告）日：2010-04-15

  The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

  本发明涉及吡唑甲基胺基哌嗪衍生物及其药用盐，其作为钙通道调节剂具有有效性，以及其制造方法。本发明还涉及上述化合物的药用作用，用于治疗因其作为钙通道调节剂而产生的疾病。
• Synthesis of Diarylmethanes via Metal-Free Reductive Cross-Coupling of Diarylborinic Acids with Tosyl Hydrazones
  作者：Xijing Li、Yuanyuan Feng、Lin Lin、Gang Zou

  DOI：10.1021/jo302207b

  日期：2012.12.7

  that takes advantage of diarylborinic acids as a cost-effective alternative to arylboronic acids for synthesis of diarylmethanes through metal-free reductive cross-coupling with N-tosylhydrazones of aromatic aldehydes and ketones. The procedure tolerates hydroxyl, halide, amine, and allyl functionality, complementary to the transition-metal catalyzed cross-coupling techniques.

  本文介绍了一种实用有效的方法，该方法利用二芳基硼酸作为芳基硼酸的经济有效替代品，通过无金属的还原性与芳族醛和酮的N-甲苯磺酰hydr偶合来合成二芳基甲烷。该方法可耐受羟基，卤化物，胺和烯丙基官能团，与过渡金属催化的交叉偶联技术互补。
• Benzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0113226A1

  公开（公告）日：1984-07-11

  The invention relates to benzhydrylpiperazine derivatives having the following general formula: wherein A is lower alkylene, Z is benzhydryl optionally substituted with halogen, and R' is amino, aryl, pyridyl, acyl or acylamino, in which the aryl group and pyridyl group are substituted with nitro, amino or acylamino, provided that Z is benzhydryl substituted with halogen, when R1 is amino, and to pharmaceutically acceptable salts thereof. These compounds possess anti-allergic activities and are effective in the treatment of allergic symptoms. The invention further relates to processes for the preparation of these compounds and to pharmaceutical compositions containing them.

  本发明涉及具有以下通式的苯甲基哌嗪衍生物：其中 A 为低级亚烷基，Z 为可选被卤素取代的苯甲基，R'为氨基、芳基、吡啶基、酰基或酰氨基，其中芳基和吡啶基被硝基、氨基或酰氨基取代，但当 R1 为氨基时，Z 为被卤素取代的苯甲基，本发明还涉及其药学上可接受的盐类。 这些化合物具有抗过敏活性，可有效治疗过敏症状。 本发明还涉及制备这些化合物的工艺以及含有这些化合物的药物组合物。